|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:histidase
gptkb:histidinase
|
|
gptkbp:biologicalProcess
|
ammonia-lyase activity
|
|
gptkbp:CASNumber
|
9029-40-9
|
|
gptkbp:catalyzes
|
deamination of L-histidine to urocanate
|
|
gptkbp:cofactor
|
none (uses a covalently bound prosthetic group, not a typical cofactor)
|
|
gptkbp:deficiencyCauses
|
histidinemia
|
|
gptkbp:EC_number
|
4.3.1.3
|
|
gptkbp:first_step_in
|
histidine degradation pathway
|
|
gptkbp:foundIn
|
gptkb:Bacteria
animals
fungi
plants
|
|
gptkbp:gene
|
gptkb:HAL
|
|
gptkbp:GO_term
|
GO:0004411
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Histidine ammonia-lyase
|
|
gptkbp:inhibitedBy
|
urocanic acid (feedback inhibition)
|
|
gptkbp:location
|
gptkb:cytoplasm
|
|
gptkbp:OMIM
|
609457
|
|
gptkbp:pathway
|
histidine catabolism
|
|
gptkbp:product
|
gptkb:urocanate
ammonia
|
|
gptkbp:structure
|
homotetramer
|
|
gptkbp:substrate
|
gptkb:L-histidine
|
|
gptkbp:systematicName
|
gptkb:L-histidine_ammonia-lyase
|
|
gptkbp:type
|
L-histidine → urocanate + NH3
|
|
gptkbp:UniProtID
|
P42357
|
|
gptkbp:used_in
|
diagnosis of histidinemia
|
|
gptkbp:bfsParent
|
gptkb:HALS
|
|
gptkbp:bfsLayer
|
6
|