|
gptkbp:instanceOf
|
gptkb:G_protein-coupled_receptor
|
|
gptkbp:alternativeSplicing
|
multiple isoforms
|
|
gptkbp:associatedWith
|
cognition
obesity
attention
narcolepsy
allergic responses
sleep-wake regulation
|
|
gptkbp:binds
|
gptkb:histamine
|
|
gptkbp:couplingType
|
gptkb:Gi/o_proteins
|
|
gptkbp:discoveredBy
|
1983
|
|
gptkbp:encodedBy
|
gptkb:HRH3_gene
|
|
gptkbp:enemyOf
|
gptkb:ciproxifan
gptkb:immepip
gptkb:pitolisant
(R)-α-methylhistamine
|
|
gptkbp:expressedIn
|
gptkb:spinal_cord
brain
peripheral tissues
|
|
gptkbp:function
|
modulation of neurotransmitter release
|
|
gptkbp:HGNC_ID
|
5170
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Histamine H3 receptor
|
|
gptkbp:inhibitedBy
|
gptkb:adenylate_cyclase
|
|
gptkbp:IUPHAR/BPS_Guide_to_Pharmacology_ID
|
124
|
|
gptkbp:locatedOnChromosome
|
20q13.33
|
|
gptkbp:location
|
central nervous system
peripheral nervous system
|
|
gptkbp:modulatedBy
|
cAMP levels
|
|
gptkbp:OMIM
|
604867
|
|
gptkbp:orthologIn
|
mouse Hrh3
rat Hrh3
|
|
gptkbp:regulates
|
dopamine release
GABA release
acetylcholine release
glutamate release
norepinephrine release
serotonin release
histamine synthesis
|
|
gptkbp:targetOfDrug
|
gptkb:Alzheimer's_disease
gptkb:attention_deficit_hyperactivity_disorder
epilepsy
schizophrenia
pain management
cognitive disorders
obesity treatments
wakefulness disorders
|
|
gptkbp:UniProtID
|
Q9Y5N1
|
|
gptkbp:bfsParent
|
gptkb:CHEMBL2108508
gptkb:HRH3_gene
|
|
gptkbp:bfsLayer
|
7
|