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gptkbp:instanceOf
|
genetic disorder
bleeding disorder
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|
gptkbp:affects
|
males predominantly
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|
gptkbp:alsoKnownAs
|
gptkb:classic_hemophilia
|
|
gptkbp:causedBy
|
deficiency of factor VIII
|
|
gptkbp:complication
|
inhibitor development
hemarthrosis
intracranial hemorrhage
|
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gptkbp:diagnosedBy
|
genetic testing
factor VIII activity assay
|
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gptkbp:differentialDiagnosis
|
gptkb:von_Willebrand_disease
gptkb:Hemophilia_B
|
|
gptkbp:firstDescribed
|
gptkb:John_Conrad_Otto
|
|
gptkbp:frequency
|
most common type of hemophilia
|
|
gptkbp:gene
|
gptkb:F8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Hemophilia A
|
|
gptkbp:ICD-10_code
|
D66
|
|
gptkbp:inheritance
|
X-linked recessive
|
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gptkbp:locatedOnChromosome
|
gptkb:Xq28
|
|
gptkbp:notableCase
|
European royal families
|
|
gptkbp:OMIM
|
306700
|
|
gptkbp:prevalence
|
1 in 5,000 male births
|
|
gptkbp:prognosis
|
improved with modern therapy
|
|
gptkbp:riskFactor
|
family history of hemophilia
|
|
gptkbp:symptom
|
easy bruising
prolonged bleeding
spontaneous joint bleeding
|
|
gptkbp:treatment
|
desmopressin (mild cases)
factor VIII replacement therapy
|
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gptkbp:bfsParent
|
gptkb:Xq28
|
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gptkbp:bfsLayer
|
6
|