Hematopoietic Stem Cell Transplantation
GPTKB entity
Statements (55)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
medical procedure
|
| gptkbp:alsoKnownAs |
HSCT
|
| gptkbp:canBe |
gptkb:severe_combined_immunodeficiency_(SCID)
gptkb:anemia multiple myeloma sickle cell disease myelodysplastic syndromes |
| gptkbp:canBeCurative |
some cancers
some genetic disorders some immune deficiencies |
| gptkbp:complication |
infertility
mucositis secondary malignancies graft failure |
| gptkbp:contraindication |
active infection
severe organ dysfunction uncontrolled disease |
| gptkbp:cookingMethod |
stem cell mobilization
cryopreservation (for autologous) stem cell collection |
| gptkbp:firstPerformed |
1957
|
| gptkbp:followedBy |
long-term monitoring
|
| gptkbp:goal |
replace diseased bone marrow
restore hematopoietic function |
| https://www.w3.org/2000/01/rdf-schema#label |
Hematopoietic Stem Cell Transplantation
|
| gptkbp:improvesSurvival |
aplastic anemia
lymphomas certain leukemias |
| gptkbp:inventedBy |
gptkb:E._Donnall_Thomas
|
| gptkbp:involves |
infusion of hematopoietic stem cells
|
| gptkbp:performedAt |
specialized medical centers
|
| gptkbp:recipientConditioning |
radiation therapy
chemotherapy |
| gptkbp:requires |
supportive care
HLA matching (for allogeneic) donor stem cells (for allogeneic) immunosuppression (for allogeneic) patient's own stem cells (for autologous) |
| gptkbp:restored |
weeks to months
|
| gptkbp:riskFactor |
gptkb:graft-versus-host_disease
infection organ toxicity relapse of underlying disease |
| gptkbp:sourceOfStemCells |
bone marrow
peripheral blood umbilical cord blood |
| gptkbp:type |
allogeneic
autologous syngeneic |
| gptkbp:usedFor |
treatment of certain cancers
treatment of bone marrow failure syndromes treatment of hematologic diseases treatment of immune deficiency disorders |
| gptkbp:bfsParent |
gptkb:Cell_Therapy
|
| gptkbp:bfsLayer |
6
|