Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:cofactor |
Mg2+
Mn2+ |
| gptkbp:discoveredBy |
1980s
|
| gptkbp:domain |
gptkb:C-terminal_DNA-binding_domain
gptkb:N-terminal_zinc-binding_domain catalytic core domain |
| gptkbp:EC_number |
2.7.7.49
|
| gptkbp:encodedBy |
gptkb:pol_gene
|
| gptkbp:foundIn |
gptkb:HIV
|
| gptkbp:function |
integration of viral DNA into host genome
|
| gptkbp:GO_term |
GO:0003677
|
| https://www.w3.org/2000/01/rdf-schema#label |
HIV integrase
|
| gptkbp:inhibitedBy |
gptkb:dolutegravir
gptkb:elvitegravir gptkb:raltegravir |
| gptkbp:molecularWeight |
32 kDa
|
| gptkbp:PDB |
gptkb:1EX4
|
| gptkbp:presentIn |
retroviruses
|
| gptkbp:processor |
3'-processing
strand transfer |
| gptkbp:requires |
HIV replication
|
| gptkbp:structure |
composed of three domains
|
| gptkbp:target |
gptkb:integrase_inhibitors
|
| gptkbp:targetOfDrug |
antiretroviral therapy
|
| gptkbp:UniProtID |
P12497
|
| gptkbp:bfsParent |
gptkb:NRTIs
|
| gptkbp:bfsLayer |
5
|