|
gptkbp:instanceOf
|
gptkb:protein
gptkb:G_protein-coupled_receptor
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:binds
|
gptkb:glucagon
|
|
gptkbp:category
|
gptkb:cell_membrane
signal transduction protein
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodedBy
|
gptkb:GCGR_gene
|
|
gptkbp:ensembl
|
ENSG00000115170
|
|
gptkbp:Entrez_Gene_ID
|
2642
|
|
gptkbp:expressedIn
|
gptkb:adipose_tissue
gptkb:kidney
heart
liver
|
|
gptkbp:family
|
gptkb:Class_B_GPCR
|
|
gptkbp:foundIn
|
gptkb:human
gptkb:mouse
gptkb:right
|
|
gptkbp:function
|
regulation of glucose metabolism
activation of adenylate cyclase
increase in cAMP levels
|
|
gptkbp:HGNC_ID
|
4193
|
|
gptkbp:length
|
477 amino acids
|
|
gptkbp:locatedIn
|
gptkb:cell_membrane
|
|
gptkbp:locatedOnChromosome
|
gptkb:17q25
chromosome 17q25.3
|
|
gptkbp:modulatedBy
|
lipolysis
glycogenolysis
gluconeogenesis
|
|
gptkbp:molecularWeight
|
53 kDa
|
|
gptkbp:mutationAssociatedWith
|
familial hyperglucagonemia
non-insulinoma pancreatogenous hypoglycemia
|
|
gptkbp:OMIM
|
138130
|
|
gptkbp:orthologIn
|
gptkb:mouse_Gcgr
gptkb:rat_Gcgr
|
|
gptkbp:PDB
|
5YQZ
|
|
gptkbp:RefSeq
|
NM_000160
|
|
gptkbp:relatedTo
|
gptkb:type_2_diabetes
glucose homeostasis
|
|
gptkbp:structure
|
seven transmembrane domains
|
|
gptkbp:symbol
|
GCGR
|
|
gptkbp:target
|
antidiabetic drugs
|
|
gptkbp:targetOfDrug
|
glucagon receptor antagonists
|
|
gptkbp:type
|
Gs protein pathway
|
|
gptkbp:UniProtID
|
P47871
|
|
gptkbp:bfsParent
|
gptkb:G_protein-coupled_receptors_(Class_IB)
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Glucagon receptor
|