Statements (25)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
heterotrimeric G protein
|
| gptkbp:activatedBy |
gptkb:adenylate_cyclase
GPCRs (G protein-coupled receptors) |
| gptkbp:alsoKnownAs |
gptkb:Gs_protein
|
| gptkbp:component |
gptkb:plasma_membrane
|
| gptkbp:decommissioned |
GTP hydrolysis
|
| gptkbp:discoveredBy |
gptkb:Alfred_G._Gilman
|
| gptkbp:encodedBy |
GNAS gene (Gαs subunit)
|
| gptkbp:foundIn |
eukaryotic cells
|
| https://www.w3.org/2000/01/rdf-schema#label |
G protein Gs
|
| gptkbp:improves |
cAMP production
|
| gptkbp:involvedIn |
hormone signaling
neurotransmitter signaling olfactory signaling |
| gptkbp:molecularWeight |
~80 kDa (heterotrimer)
|
| gptkbp:mutationAssociatedWith |
gptkb:McCune-Albright_syndrome
pseudohypoparathyroidism |
| gptkbp:NobelPrizeYear |
Nobel Prize in Physiology or Medicine 1994 (to Gilman and Rodbell)
|
| gptkbp:regulates |
protein kinase A (PKA) activity
|
| gptkbp:subunit |
Gαs
Gβ Gγ |
| gptkbp:type |
G protein-coupled receptor pathway
|
| gptkbp:bfsParent |
gptkb:Guanine_nucleotide-binding_protein_G(s),_alpha_subunit
|
| gptkbp:bfsLayer |
8
|