G protein Gs

GPTKB entity

Statements (25)
Predicate Object
gptkbp:instanceOf heterotrimeric G protein
gptkbp:activatedBy gptkb:adenylate_cyclase
GPCRs (G protein-coupled receptors)
gptkbp:alsoKnownAs gptkb:Gs_protein
gptkbp:component gptkb:plasma_membrane
gptkbp:decommissioned GTP hydrolysis
gptkbp:discoveredBy gptkb:Alfred_G._Gilman
gptkbp:encodedBy GNAS gene (Gαs subunit)
gptkbp:foundIn eukaryotic cells
https://www.w3.org/2000/01/rdf-schema#label G protein Gs
gptkbp:improves cAMP production
gptkbp:involvedIn hormone signaling
neurotransmitter signaling
olfactory signaling
gptkbp:molecularWeight ~80 kDa (heterotrimer)
gptkbp:mutationAssociatedWith gptkb:McCune-Albright_syndrome
pseudohypoparathyroidism
gptkbp:NobelPrizeYear Nobel Prize in Physiology or Medicine 1994 (to Gilman and Rodbell)
gptkbp:regulates protein kinase A (PKA) activity
gptkbp:subunit Gαs


gptkbp:type G protein-coupled receptor pathway
gptkbp:bfsParent gptkb:Guanine_nucleotide-binding_protein_G(s),_alpha_subunit
gptkbp:bfsLayer 8