|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activeSiteResidue
|
gptkb:aspartate
arginine
histidine
|
|
gptkbp:alternativeName
|
gptkb:fumarate_hydratase
gptkb:fumarate_hydratase_class_II
|
|
gptkbp:CASNumber
|
gptkb:9024-67-7
|
|
gptkbp:catalyzes
|
conversion of fumarate to malate
|
|
gptkbp:cofactor
|
none
|
|
gptkbp:deficiencyCauses
|
gptkb:fumarase_deficiency
|
|
gptkbp:discoveredBy
|
gptkb:Albert_Szent-Györgyi
|
|
gptkbp:EC_number
|
4.2.1.2
|
|
gptkbp:enzymeClassification
|
lyase
|
|
gptkbp:expressedIn
|
gptkb:thyroid
gptkb:cancer
gptkb:skeletal_muscle
gptkb:kidney
gptkb:placenta
gptkb:prostate
gptkb:small_intestine
gptkb:testis
brain
heart
liver
spleen
adipose tissue
bladder
colon
esophagus
pancreas
|
|
gptkbp:foundIn
|
mitochondria
cytosol
|
|
gptkbp:gene
|
gptkb:FH
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Fumarase
|
|
gptkbp:inhibitedBy
|
succinate
malonate
|
|
gptkbp:involves
|
citric acid cycle
|
|
gptkbp:locatedOnChromosome
|
1q42.1
|
|
gptkbp:molecularWeight
|
about 200 kDa (tetramer)
|
|
gptkbp:mutationAssociatedWith
|
gptkb:hereditary_leiomyomatosis_and_renal_cell_cancer
|
|
gptkbp:PDB
|
gptkb:1FUO
|
|
gptkbp:presentIn
|
all domains of life
|
|
gptkbp:product
|
gptkb:L-malate
|
|
gptkbp:structure
|
homotetramer
|
|
gptkbp:substrate
|
fumarate
|
|
gptkbp:systematicName
|
gptkb:(S)-malate_hydro-lyase
|
|
gptkbp:type
|
hydration/dehydration
|
|
gptkbp:UniProtID
|
gptkb:P07954
|
|
gptkbp:bfsParent
|
gptkb:Enzymes
|
|
gptkbp:bfsLayer
|
6
|