Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
fumarase
|
| gptkbp:associatedWith |
gptkb:fumarase_deficiency
gptkb:hereditary_leiomyomatosis_and_renal_cell_cancer |
| gptkbp:biologicalProcess |
lyase activity
|
| gptkbp:catalyzes |
hydration of fumarate to malate
|
| gptkbp:cofactor |
none required
|
| gptkbp:deficiencyCauses |
neurological impairment
|
| gptkbp:EC_number |
4.2.1.2
|
| gptkbp:foundIn |
mitochondria
cytosol |
| gptkbp:gene |
gptkb:FH
|
| gptkbp:inhibitedBy |
mercaptosuccinate
|
| gptkbp:locatedOnChromosome |
chromosome 1q42.1
|
| gptkbp:OMIM |
136850
|
| gptkbp:part_of |
citric acid cycle
|
| gptkbp:product |
gptkb:L-malate
|
| gptkbp:structure |
homotetramer
|
| gptkbp:substrate |
fumarate
|
| gptkbp:UniProtID |
gptkb:P07954
|
| gptkbp:bfsParent |
gptkb:Fumarase
|
| gptkbp:bfsLayer |
7
|
| https://www.w3.org/2000/01/rdf-schema#label |
fumarate hydratase
|