|
gptkbp:instanceOf
|
gptkb:chemical_compound
gptkb:drug
|
|
gptkbp:administeredBy
|
gptkb:5-fluorouracil
|
|
gptkbp:alternativeName
|
gptkb:leucovorin
|
|
gptkbp:ATCCode
|
V03AF03
|
|
gptkbp:CASNumber
|
58-05-9
|
|
gptkbp:category
|
gptkb:vitamin_A
antidote
antineoplastic adjuvant
|
|
gptkbp:chemicalFormula
|
C20H23N7O7
|
|
gptkbp:contraindication
|
pernicious anemia
vitamin B12 deficiency
|
|
gptkbp:derivedFrom
|
tetrahydrofolic acid
|
|
gptkbp:discoveredBy
|
1945
|
|
gptkbp:eliminationHalfLife
|
6 hours
|
|
gptkbp:excretion
|
gptkb:kidney
|
|
gptkbp:foundIn
|
prescription medications
|
|
gptkbp:has_stereochemistry
|
levofolinic acid
racemic folinic acid
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Folinic acid
|
|
gptkbp:includedIn
|
gptkb:WHO_Model_List_of_Essential_Medicines
|
|
gptkbp:interactsWith
|
gptkb:phenytoin
gptkb:5-fluorouracil
gptkb:methotrexate
phenobarbital
primidone
|
|
gptkbp:KEGGID
|
D00568
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
bypasses dihydrofolate reductase
|
|
gptkbp:meltingPoint
|
250 °C
|
|
gptkbp:MeSH_ID
|
D005494
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
473.44 g/mol
|
|
gptkbp:pregnancyCategory
|
A (Australia)
|
|
gptkbp:PubChem_CID
|
68521
CHEMBL1201207
DB00650
|
|
gptkbp:routeOfAdministration
|
oral
intramuscular
intravenous
|
|
gptkbp:sideEffect
|
fever
seizures
allergic reactions
trouble sleeping
|
|
gptkbp:UNII
|
O8C8OZ26ZF
|
|
gptkbp:usedFor
|
enhance 5-fluorouracil chemotherapy
reduce toxicity of methotrexate
treat folic acid antagonist overdose
|
|
gptkbp:bfsParent
|
gptkb:Toxoplasmosis
|
|
gptkbp:bfsLayer
|
5
|