Fms-related tyrosine kinase 4
GPTKB entity
Statements (26)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
gptkb:FLT4
gptkb:VEGFR-3 |
| gptkbp:associatedWith |
gptkb:Milroy_disease
lymphedema |
| gptkbp:discoveredIn |
1990s
|
| gptkbp:encodedBy |
gptkb:FLT4_gene
|
| gptkbp:Entrez_Gene_ID |
2324
|
| gptkbp:expressedIn |
lymphatic endothelial cells
|
| gptkbp:function |
gptkb:receptor_tyrosine_kinase
lymphangiogenesis |
| https://www.w3.org/2000/01/rdf-schema#label |
Fms-related tyrosine kinase 4
|
| gptkbp:ligand |
gptkb:VEGF-C
gptkb:VEGF-D |
| gptkbp:locatedOnChromosome |
gptkb:chromosome_5q35.3
|
| gptkbp:location |
gptkb:plasma_membrane
|
| gptkbp:molecularWeight |
~195 kDa
|
| gptkbp:OMIM |
136352
|
| gptkbp:orthologInMouse |
Flt4
|
| gptkbp:PDB |
4BSJ
|
| gptkbp:phosphorylates |
autophosphorylation upon ligand binding
|
| gptkbp:role |
lymphatic vessel formation
|
| gptkbp:target |
anti-angiogenic drugs
|
| gptkbp:UniProtID |
P35916
|
| gptkbp:bfsParent |
gptkb:VEGFR3
|
| gptkbp:bfsLayer |
6
|