Statements (60)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:Genetics
|
| gptkbp:acquired_by |
functional assays
|
| gptkbp:affects |
immune response
patient quality of life complement system blood coagulation |
| gptkbp:are_diagnosed_by |
genetic testing
|
| gptkbp:are_identified_in |
familial cases
|
| gptkbp:are_part_of |
gptkb:hereditary_angioedema
complement system disorders |
| gptkbp:associated_with |
C3 glomerulopathy
|
| gptkbp:can_cause |
edema
thrombotic microangiopathy hemolytic uremic syndrome |
| gptkbp:can_detect |
serum complement levels
|
| gptkbp:can_lead_to |
chronic kidney disease
diagnostic challenges increased susceptibility to infections recurrent abdominal pain reduced Factor I activity |
| gptkbp:can_result_in |
inflammatory responses
complement component deficiencies dysregulation of immune system |
| gptkbp:caused_by |
variations in the SERPING1 gene
|
| https://www.w3.org/2000/01/rdf-schema#label |
Factor I mutations
|
| gptkbp:influence |
treatment outcomes
|
| gptkbp:inherits_from |
in an autosomal dominant manner
|
| gptkbp:is_affected_by |
environmental factors
|
| gptkbp:is_associated_with |
chronic inflammation
autoimmune disorders systemic complications increased risk of thrombosis poor prognosis in some cases |
| gptkbp:is_characterized_by |
recurrent infections
variable expressivity |
| gptkbp:is_essential_for |
understanding complement biology
|
| gptkbp:is_involved_in |
complement activation pathways
pathogenesis of glomerulonephritis research on complement inhibitors |
| gptkbp:is_linked_to |
gptkb:systemic_lupus_erythematosus
complement-mediated diseases nephritis genetic counseling needs complement factor deficiencies |
| gptkbp:is_managed_by |
plasma infusions
|
| gptkbp:is_part_of |
diagnostic criteria for diseases
|
| gptkbp:is_recognized_by |
gptkb:guidelines
next-generation sequencing. |
| gptkbp:is_related_to |
C4b-binding protein deficiency
|
| gptkbp:is_relevant_to |
personalized medicine approaches
clinical management strategies |
| gptkbp:is_significant_for |
understanding immune deficiencies
|
| gptkbp:is_studied_for |
gene therapy approaches
|
| gptkbp:is_studied_in |
animal models
clinical research |
| gptkbp:requires |
complement replacement therapy
|
| gptkbp:resulted_in |
uncontrolled complement activation
|
| gptkbp:treatment |
immunosuppressive therapy
|
| gptkbp:bfsParent |
gptkb:Atypical_Hemolytic_Uremic_Syndrome
|
| gptkbp:bfsLayer |
7
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