|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
Alpha-ketoglutarate-dependent dioxygenase FTO
|
|
gptkbp:associatedWith
|
gptkb:type_2_diabetes
gptkb:body_mass_index
gptkb:metabolic_syndrome
obesity
|
|
gptkbp:cofactor
|
gptkb:2-oxoglutarate
Fe2+
|
|
gptkbp:discoveredBy
|
2007
|
|
gptkbp:encodedBy
|
FTO gene
|
|
gptkbp:Entrez_Gene_ID
|
79068
|
|
gptkbp:enzymeCommissionNumber
|
EC 1.14.11.2
|
|
gptkbp:fullName
|
Fat mass and obesity-associated protein
|
|
gptkbp:function
|
RNA modification
demethylase
|
|
gptkbp:GO_term
|
gptkb:GO:0006355_(regulation_of_transcription,_DNA-templated)
GO:0003677 (DNA binding)
GO:0031072 (HIF-1alpha binding)
|
|
gptkbp:HGNC_ID
|
24678
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FTO protein
|
|
gptkbp:inhibitedBy
|
meclofenamic acid
rhein
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_16
|
|
gptkbp:location
|
gptkb:nucleus
|
|
gptkbp:molecularWeight
|
58 kDa
|
|
gptkbp:mutationAssociatedWith
|
increased risk of obesity
|
|
gptkbp:OMIM
|
610966
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:pathway
|
epigenetic regulation
mRNA demethylation
|
|
gptkbp:PDB
|
3LFM
|
|
gptkbp:postTranslationalModification
|
phosphorylation
|
|
gptkbp:RefSeq
|
NP_001073901.1
|
|
gptkbp:reviewedBy
|
gptkb:Cell_Metabolism
gptkb:science
gptkb:Nature_Genetics
|
|
gptkbp:structure
|
contains Fe(II) and 2-oxoglutarate binding sites
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
nucleoplasm
|
|
gptkbp:substrate
|
N6-methyladenosine (m6A) in RNA
|
|
gptkbp:tissue_specificity
|
gptkb:skeletal_muscle
brain
liver
adipose tissue
pancreas
|
|
gptkbp:UniProtID
|
Q9C0B1
|
|
gptkbp:bfsParent
|
gptkb:fat_mass_and_obesity_associated
gptkb:ENSG00000113525
gptkb:ENSG00000117461
|
|
gptkbp:bfsLayer
|
7
|