FTO, alpha-ketoglutarate dependent dioxygenase

URI: https://gptkb.org/entity/FTO,_alpha-ketoglutarate_dependent_dioxygenase
GPTKB entity
Statements (37)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alternativeName Fat mass and obesity-associated protein
gptkbp:associatedWith gptkb:body_mass_index
obesity
gptkbp:biologicalProcess oxidoreductase activity
RNA modification
regulation of energy homeostasis
regulation of adipogenesis
gptkbp:cofactor gptkb:alpha-ketoglutarate
Fe(II)
gptkbp:discoveredIn 2007
gptkbp:encodedBy FTO gene
gptkbp:Entrez_Gene_ID 79068
gptkbp:enzymeCommissionNumber 1.14.11.2
gptkbp:expressedIn gptkb:skeletal_muscle
brain
adipose tissue
pancreas
gptkbp:foundIn gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkbp:function demethylation of nucleic acids
https://www.w3.org/2000/01/rdf-schema#label FTO, alpha-ketoglutarate dependent dioxygenase
gptkbp:locatedIn gptkb:nucleus
gptkbp:locatedOnChromosome gptkb:16q12.2
gptkbp:mutationAssociatedWith increased risk of obesity
gptkbp:OMIM 610966
gptkbp:PDB 3LFM
gptkbp:substrate N6-methyladenosine (m6A)
gptkbp:UniProtID Q9C0B1
gptkbp:bfsParent gptkb:ENSG00000115414
gptkb:ENSG00000101412
gptkb:ENSG00000111783
gptkb:ENSG00000142319
gptkb:ENSG00000107862
gptkb:ENSG00000120875
gptkbp:bfsLayer 8