FTO, alpha-ketoglutarate dependent dioxygenase

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:alternativeName	Fat mass and obesity-associated protein
gptkbp:associatedWith	gptkb:body_mass_index obesity
gptkbp:biologicalProcess	oxidoreductase activity RNA modification regulation of energy homeostasis regulation of adipogenesis
gptkbp:cofactor	gptkb:alpha-ketoglutarate Fe(II)
gptkbp:discoveredIn	2007
gptkbp:encodedBy	FTO gene
gptkbp:Entrez_Gene_ID	79068
gptkbp:enzymeCommissionNumber	1.14.11.2
gptkbp:expressedIn	gptkb:adipose_tissue gptkb:skeletal_muscle brain pancreas
gptkbp:foundIn	gptkb:Mus_musculus gptkb:Homo_sapiens
gptkbp:function	demethylation of nucleic acids
gptkbp:locatedIn	gptkb:nucleus
gptkbp:locatedOnChromosome	gptkb:16q12.2
gptkbp:mutationAssociatedWith	increased risk of obesity
gptkbp:OMIM	610966
gptkbp:PDB	3LFM
gptkbp:substrate	N6-methyladenosine (m6A)
gptkbp:UniProtID	Q9C0B1
gptkbp:bfsParent	gptkb:ENSG00000115414 gptkb:ENSG00000101412 gptkb:ENSG00000111783 gptkb:ENSG00000142319 gptkb:ENSG00000107862 gptkb:ENSG00000120875
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	FTO, alpha-ketoglutarate dependent dioxygenase