|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
alpha-ketoglutarate-dependent dioxygenase FTO
|
|
gptkbp:amendedBy
|
N6-methyladenosine (m6A) demethylation
|
|
gptkbp:associatedWith
|
gptkb:type_2_diabetes
gptkb:metabolic_syndrome
obesity
|
|
gptkbp:biologicalProcess
|
DNA demethylation
RNA demethylation
|
|
gptkbp:discoveredBy
|
2007
|
|
gptkbp:encodedBy
|
FTO gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000140718
|
|
gptkbp:expressedIn
|
brain
adipose tissue
|
|
gptkbp:firstDescribed
|
gptkb:Nature_Genetics
2007
Frayling et al.
|
|
gptkbp:fullName
|
Fat mass and obesity-associated protein
|
|
gptkbp:function
|
regulation of energy homeostasis
demethylase
|
|
gptkbp:gene
|
gptkb:FTO
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:24678
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FTO
|
|
gptkbp:interactsWith
|
gptkb:gene
ALKBH5
|
|
gptkbp:length
|
505 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:16q12.2
|
|
gptkbp:mutationAssociatedWith
|
increased risk of obesity
|
|
gptkbp:OMIM
|
610966
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
m6A RNA modification
|
|
gptkbp:PDB
|
3LFM
|
|
gptkbp:proteinFamily
|
AlkB family
|
|
gptkbp:regulates
|
gptkb:body_mass_index
food intake
adipogenesis
|
|
gptkbp:significance
|
risk factor for obesity
risk factor for type 2 diabetes
|
|
gptkbp:SNP
|
rs1421085
rs8050136
rs9939609
|
|
gptkbp:structure
|
contains AlkB-like domain
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:tissue_specificity
|
high in hypothalamus
|
|
gptkbp:UniProtID
|
Q9C0B1
|
|
gptkbp:bfsParent
|
gptkb:ENSG00000121879
|
|
gptkbp:bfsLayer
|
6
|