Statements (60)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:Oncology
cell signaling |
| gptkbp:has_role |
tumorigenesis
|
| https://www.w3.org/2000/01/rdf-schema#label |
Erb B family
|
| gptkbp:includes |
gptkb:EGFR
Erb B2 Erb B3 Erb B4 |
| gptkbp:interacts_with |
ligands
|
| gptkbp:involved_in |
cell proliferation
differentiation survival signaling |
| gptkbp:is_associated_with |
gptkb:Oncology
ovarian cancer head and neck cancer |
| gptkbp:is_expressed_in |
heart tissue
breast tissue lung tissue neuronal tissues epithelial tissues |
| gptkbp:is_involved_in |
gptkb:embryonic_development
apoptosis cell cycle regulation immune response wound healing neurogenesis angiogenesis neurotransmission cell adhesion cell migration metastasis response to infection stem cell maintenance tissue homeostasis response to inflammation metabolic regulation hormonal signaling response to stress response to injury response to hypoxia response to oxidative stress response to radiation |
| gptkbp:is_part_of |
signal transduction pathways
receptor tyrosine kinases |
| gptkbp:is_regulated_by |
growth factors
cytokines |
| gptkbp:is_targeted_at |
gptkb:neratinib
gptkb:trastuzumab gptkb:lapatinib cetuximab panitumumab |
| gptkbp:subfamily |
Erb B1
Erb B2 Erb B3 Erb B4 |
| gptkbp:targets |
monoclonal antibodies
tyrosine kinase inhibitors |
| gptkbp:bfsParent |
gptkb:EGFR
|
| gptkbp:bfsLayer |
5
|