Endometrial carcinoma

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:cancer
Gynecologic cancer
gptkbp:affects gptkb:Uterus
Endometrium
gptkbp:associatedWith PTEN mutation
MLH1 mutation
MSH2 mutation
P53 mutation
gptkbp:canMetastasizeTo gptkb:bone
Lungs
Liver
Lymph nodes
gptkbp:commonIn Postmenopausal women
gptkbp:diagnosedBy Dilation and curettage
Endometrial biopsy
Transvaginal ultrasound
gptkbp:firstDescribed 19th century
gptkbp:hasScreening No standard screening
https://www.w3.org/2000/01/rdf-schema#label Endometrial carcinoma
gptkbp:ICD-10_code gptkb:C54.1
gptkbp:incidence Most common gynecologic malignancy in developed countries
gptkbp:marking CA-125 (sometimes elevated)
gptkbp:predecessor Endometrial hyperplasia
gptkbp:prevalence More common in developed countries
gptkbp:prognosis Good if detected early
gptkbp:riskFactor gptkb:Lynch_syndrome
gptkb:Diabetes_mellitus
gptkb:Polycystic_ovary_syndrome
Obesity
Hypertension
Early menarche
Late menopause
Nulliparity
Tamoxifen use
Unopposed estrogen exposure
gptkbp:stageName gptkb:FIGO_staging
gptkbp:subspecies gptkb:Clear_cell_carcinoma
gptkb:Endometrioid_adenocarcinoma
gptkb:Serous_carcinoma
gptkbp:symptom Weight loss
Abnormal uterine bleeding
Pelvic pain
Postmenopausal bleeding
gptkbp:treatment radiation therapy
Surgery
Chemotherapy
Hysterectomy
Hormonal therapy
gptkbp:bfsParent gptkb:Uterine_cancer
gptkbp:bfsLayer 7