|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:EF-Tu
|
|
gptkbp:binds
|
gptkb:GTP
aminoacyl-tRNA
|
|
gptkbp:component
|
cytosol
|
|
gptkbp:conservedIn
|
prokaryotes
highly conserved
|
|
gptkbp:deliveredBy
|
aminoacyl-tRNA to ribosome
|
|
gptkbp:discoveredBy
|
gptkb:M._Nomura
|
|
gptkbp:discoveredIn
|
1960s
|
|
gptkbp:encodedBy
|
gptkb:tufA_gene
gptkb:tufB_gene
|
|
gptkbp:function
|
guanine nucleotide exchange factor
GTP binding
translation elongation factor
translation elongation factor activity
|
|
gptkbp:GOProcess
|
translator
|
|
gptkbp:GTPHydrolysis
|
required for tRNA release
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Elongation Factor Tu
|
|
gptkbp:inhibitedBy
|
gptkb:pulvomycin
gptkb:enacyloxin_IIa
gptkb:kirromycin
GE2270A
|
|
gptkbp:interactsWith
|
gptkb:Elongation_Factor_Ts
ribosome
|
|
gptkbp:locatedOnChromosome
|
bacterial chromosome
|
|
gptkbp:molecularWeight
|
~43 kDa
|
|
gptkbp:mutationAssociatedWith
|
can cause antibiotic resistance
|
|
gptkbp:organism
|
gptkb:Bacteria
|
|
gptkbp:orthologIn
|
gptkb:eukaryotic_EF-1α
|
|
gptkbp:PDB
|
gptkb:1EFC
gptkb:1EXM
1TTT
|
|
gptkbp:postTranslationalModification
|
phosphorylation
methylation
acetylation
|
|
gptkbp:recyclesWith
|
gptkb:Elongation_Factor_Ts
|
|
gptkbp:requires
|
cell viability
|
|
gptkbp:role
|
protein biosynthesis
|
|
gptkbp:significance
|
target for antibiotics
|
|
gptkbp:structure
|
three domains
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
|
|
gptkbp:taxonRank
|
gptkb:Bacteria
gptkb:Bacillus_subtilis
gptkb:Thermus_thermophilus
|
|
gptkbp:UniProtID
|
gptkb:P0A6F5
|
|
gptkbp:bfsParent
|
gptkb:EFTU
|
|
gptkbp:bfsLayer
|
7
|