|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:NGFI-C
KROX-3
ZIF268-3
|
|
gptkbp:associatedWith
|
schizophrenia
lupus
|
|
gptkbp:contains
|
three C2H2-type zinc fingers
|
|
gptkbp:discoveredBy
|
1990s
|
|
gptkbp:DNA_binding_domain
|
zinc finger
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000162992
1960
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
immune cells
|
|
gptkbp:family
|
gptkb:EGR_family
|
|
gptkbp:fullName
|
gptkb:early_growth_response_3
|
|
gptkbp:function
|
transcription factor
|
|
gptkbp:HGNC_ID
|
3237
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Egr3
|
|
gptkbp:interactsWith
|
gptkb:CREB-binding_protein
other EGR family members
|
|
gptkbp:locatedOnChromosome
|
8
|
|
gptkbp:location
|
8p21.3
|
|
gptkbp:molecularWeight
|
~57 kDa
|
|
gptkbp:mutationAssociatedWith
|
impaired immune function in mice
muscle spindle defects in mice
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Egr3
|
|
gptkbp:product
|
gptkb:EGR3_protein
|
|
gptkbp:regulates
|
gptkb:Arc_gene
gene expression
T cell development
B cell development
neuronal plasticity
synaptic function
NMDA receptor subunits
immune cell differentiation
BDNF expression
muscle spindle morphogenesis
|
|
gptkbp:relatedTo
|
immune response
neuronal development
muscle spindle development
|
|
gptkbp:transcriptional_activator
|
yes
|
|
gptkbp:transcriptional_regulation
|
inducible by growth factors
inducible by stress
inducible by neuronal activity
|
|
gptkbp:UniProtID
|
O43524
|
|
gptkbp:bfsParent
|
gptkb:EGR3
|
|
gptkbp:bfsLayer
|
7
|