ERBB4
E903678
ERBB4 is a receptor tyrosine kinase of the ErbB/EGFR family involved in cell signaling pathways that regulate cell growth, differentiation, and development.
All labels observed (4)
| Label | Occurrences |
|---|---|
| ERBB4 canonical | 5 |
| HER4 | 2 |
| ERBB-4 | 1 |
| Receptor tyrosine-protein kinase erbB-4 | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T11074235 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: ERBB4 Context triple: [HER2 receptor, formsHeterodimerWith, ERBB4]
-
A.
ERBB3
ERBB3 is a member of the ErbB family of receptor tyrosine kinases that plays a key role in cell signaling, particularly in cancer, often through potent mitogenic and survival pathways.
-
B.
EGFR
EGFR (epidermal growth factor receptor) is a transmembrane receptor tyrosine kinase that regulates cell growth and survival and is frequently implicated in cancer development and progression.
-
C.
ERBB2
ERBB2, also known as HER2, is a receptor tyrosine kinase frequently overexpressed in certain breast and other cancers and serves as a key therapeutic target.
-
D.
HER2 receptor
The HER2 receptor is a cell surface protein and member of the epidermal growth factor receptor family that, when overexpressed, drives the growth of certain aggressive breast and other cancers.
-
E.
EWSR1
EWSR1 is a multifunctional RNA-binding protein involved in transcriptional regulation and RNA processing, best known for its role in chromosomal translocations that drive various sarcomas and leukemias.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: ERBB4 Target entity description: ERBB4 is a receptor tyrosine kinase of the ErbB/EGFR family involved in cell signaling pathways that regulate cell growth, differentiation, and development.
-
A.
ERBB3
ERBB3 is a member of the ErbB family of receptor tyrosine kinases that plays a key role in cell signaling, particularly in cancer, often through potent mitogenic and survival pathways.
-
B.
EGFR
EGFR (epidermal growth factor receptor) is a transmembrane receptor tyrosine kinase that regulates cell growth and survival and is frequently implicated in cancer development and progression.
-
C.
ERBB2
ERBB2, also known as HER2, is a receptor tyrosine kinase frequently overexpressed in certain breast and other cancers and serves as a key therapeutic target.
-
D.
HER2 receptor
The HER2 receptor is a cell surface protein and member of the epidermal growth factor receptor family that, when overexpressed, drives the growth of certain aggressive breast and other cancers.
-
E.
EWSR1
EWSR1 is a multifunctional RNA-binding protein involved in transcriptional regulation and RNA processing, best known for its role in chromosomal translocations that drive various sarcomas and leukemias.
- F. None of above. chosen
Statements (72)
| Predicate | Object |
|---|---|
| instanceOf |
ErbB receptor family member
ⓘ
human gene ⓘ protein ⓘ receptor tyrosine kinase ⓘ transmembrane receptor ⓘ |
| activatedBy |
betacellulin
ⓘ
heparin-binding EGF-like growth factor ⓘ neuregulin 1 ⓘ
linked to:
neuregulin 1 (NRG1)
neuregulin 2 ⓘ
linked to:
neuregulin 2 (NRG2)
neuregulin 3 ⓘ neuregulin 4 ⓘ |
| alsoKnownAs |
ERBB-4
ⓘ
linked to:
ERBB4
HER4 ⓘ
linked to:
ERBB4
proto-oncogene c-ERBB-4 ⓘ |
| associatedWithDisease |
bipolar disorder
ⓘ
breast cancer ⓘ medulloblastoma ⓘ melanoma ⓘ non-small cell lung cancer ⓘ schizophrenia ⓘ |
| belongsToFamily |
EGFR family
ⓘ
linked to:
epidermal growth factor receptor family
ErbB receptor family ⓘ
linked to:
epidermal growth factor receptor family
|
| encodes |
Receptor tyrosine-protein kinase erbB-4
ⓘ
linked to:
ERBB4
|
| expressedInTissue |
brain
ⓘ
heart ⓘ kidney ⓘ lung ⓘ mammary gland ⓘ |
| formsHeterodimerWith |
EGFR
ⓘ
ERBB2 ⓘ ERBB3 ⓘ |
| hasAlternativeSplicing | multiple isoforms ⓘ |
| hasBiologicalProcess |
EGFR signaling pathway
ⓘ
ERBB signaling pathway ⓘ MAPK cascade ⓘ PI3K-Akt signaling pathway ⓘ
linked to:
PI3K-AKT signaling pathway
apoptotic process regulation ⓘ cell differentiation ⓘ cell growth ⓘ cell proliferation ⓘ cell survival ⓘ embryonic development ⓘ heart development ⓘ mammary gland development ⓘ nervous system development ⓘ signal transduction ⓘ |
| hasCellularComponent |
cell surface
ⓘ
integral component of plasma membrane ⓘ plasma membrane ⓘ |
| hasDomain |
extracellular ligand-binding domain
ⓘ
intracellular tyrosine kinase domain ⓘ single-pass transmembrane domain ⓘ |
| hasEnsemblGeneID | ENSG00000178568 ⓘ |
| hasEntrezGeneID | 2066 ⓘ |
| hasHGNCID | HGNC:3431 ⓘ |
| hasMolecularFunction |
ATP binding
ⓘ
protein binding ⓘ protein tyrosine kinase activity ⓘ transmembrane receptor protein tyrosine kinase activity ⓘ |
| hasPostTranslationalModification |
proteolytic cleavage
ⓘ
tyrosine phosphorylation ⓘ |
| hasUniProtID | Q15303 ⓘ |
| locatedOnChromosome | chromosome 2 ⓘ |
| locatedOnChromosomeArm | 2q ⓘ |
| organism | Homo sapiens ⓘ |
| producesFragment | ERBB4 intracellular domain ⓘ |
| regulatesPathway |
cardiac muscle cell proliferation
ⓘ
neuronal migration ⓘ synapse development ⓘ |
| subcellularLocation |
cell membrane
ⓘ
cytoplasm ⓘ nucleus ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: ERBB4 Description of subject: ERBB4 is a receptor tyrosine kinase of the ErbB/EGFR family involved in cell signaling pathways that regulate cell growth, differentiation, and development.
Referenced by (9)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: ERBB4
linked to: ERBB4
linked to: ERBB4