CD340

E902871

CD340 is an alternative name for the human epidermal growth factor receptor 2 (HER2), a cell surface receptor tyrosine kinase often overexpressed in certain aggressive breast and gastric cancers.

All labels observed (1)

Label Occurrences
CD340 canonical 1

How this entity was disambiguated

Statements (47)

Predicate Object
instanceOf cell surface receptor
protein
receptor tyrosine kinase
activatesPathway JAK-STAT signaling pathway
MAPK/ERK signaling pathway
PI3K-AKT signaling pathway
alternativeNameOf ERBB2
HER2
linked to: ERBB2

human epidermal growth factor receptor 2
linked to: ERBB2
associatedWith aggressive breast cancer
metastasis
poor prognosis in breast cancer
poor prognosis in gastric cancer
tumor cell proliferation
tumor cell survival
encodes ERBB2 gene
linked to: ERBB2
formsComplexWith EGFR (ERBB1)
linked to: EGFR

ERBB3
ERBB4
hasBiologicalProcess cell differentiation
cell proliferation
epithelial cell development
signal transduction
hasCDDesignation CD340
hasCellularComponent cell surface
plasma membrane
hasDomain extracellular ligand-binding domain
intracellular tyrosine kinase domain
single-pass transmembrane domain
hasMolecularFunction protein tyrosine kinase activity
transmembrane receptor activity
locatedOnChromosome human chromosome 17q12
memberOf EGFR/ErbB family of receptor tyrosine kinases
ErbB receptor family
organism Homo sapiens
overexpressedIn HER2-positive breast cancer
HER2-positive gastric cancer
targetOf ado-trastuzumab emtansine
fam-trastuzumab deruxtecan
lapatinib
margetuximab
neratinib
pertuzumab
trastuzumab
linked to: Herceptin

tucatinib
usedAsBiomarkerFor HER2-positive breast cancer
HER2-positive gastric cancer

How these facts were elicited

Referenced by (1)

Full triples — surface form annotated when it differs from this entity's canonical label.