ERBB3
E902873
ERBB3 is a member of the ErbB family of receptor tyrosine kinases that plays a key role in cell signaling, particularly in cancer, often through potent mitogenic and survival pathways.
All labels observed (5)
| Label | Occurrences |
|---|---|
| ERBB3 canonical | 5 |
| ERBB3 proto-oncogene | 1 |
| HER3 | 1 |
| Receptor tyrosine-protein kinase erbB-3 | 1 |
| v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T11074234 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: ERBB3 Context triple: [HER2 receptor, formsHeterodimerWith, ERBB3]
-
A.
ERBB2
ERBB2, also known as HER2, is a receptor tyrosine kinase frequently overexpressed in certain breast and other cancers and serves as a key therapeutic target.
-
B.
EWSR1
EWSR1 is a multifunctional RNA-binding protein involved in transcriptional regulation and RNA processing, best known for its role in chromosomal translocations that drive various sarcomas and leukemias.
-
C.
HER2 receptor
The HER2 receptor is a cell surface protein and member of the epidermal growth factor receptor family that, when overexpressed, drives the growth of certain aggressive breast and other cancers.
-
D.
CDK4
CDK4 is a cyclin-dependent kinase that regulates cell cycle progression and is a key therapeutic target in certain cancers.
-
E.
EGF
EGF is the ICAO airline designator used to identify American Eagle Airlines in aviation operations and communications.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: ERBB3 Target entity description: ERBB3 is a member of the ErbB family of receptor tyrosine kinases that plays a key role in cell signaling, particularly in cancer, often through potent mitogenic and survival pathways.
-
A.
ERBB2
ERBB2, also known as HER2, is a receptor tyrosine kinase frequently overexpressed in certain breast and other cancers and serves as a key therapeutic target.
-
B.
EWSR1
EWSR1 is a multifunctional RNA-binding protein involved in transcriptional regulation and RNA processing, best known for its role in chromosomal translocations that drive various sarcomas and leukemias.
-
C.
HER2 receptor
The HER2 receptor is a cell surface protein and member of the epidermal growth factor receptor family that, when overexpressed, drives the growth of certain aggressive breast and other cancers.
-
D.
CDK4
CDK4 is a cyclin-dependent kinase that regulates cell cycle progression and is a key therapeutic target in certain cancers.
-
E.
EGF
EGF is the ICAO airline designator used to identify American Eagle Airlines in aviation operations and communications.
- F. None of above. chosen
Statements (61)
| Predicate | Object |
|---|---|
| instanceOf |
ErbB family member
ⓘ
protein-coding gene ⓘ receptor tyrosine kinase ⓘ |
| activatesPathway |
PI3K-AKT pathway
ⓘ
linked to:
PI3K-AKT signaling pathway
RAS-RAF-MEK-ERK pathway ⓘ mTOR signaling pathway ⓘ |
| alsoKnownAs |
ERBB3 proto-oncogene
ⓘ
linked to:
ERBB3
HER3 ⓘ
linked to:
ERBB3
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 ⓘ
linked to:
ERBB3
|
| associatedWithDisease |
breast cancer
ⓘ
colorectal cancer ⓘ gastric cancer ⓘ lung cancer ⓘ melanoma ⓘ ovarian cancer ⓘ prostate cancer ⓘ |
| belongsToFamily |
EGFR family
ⓘ
linked to:
epidermal growth factor receptor family
ErbB receptor family ⓘ
linked to:
epidermal growth factor receptor family
|
| bindsLigand |
neuregulin 1 (NRG1)
ⓘ
neuregulin 2 (NRG2) ⓘ |
| databaseIdentifier |
Entrez Gene:2065
ⓘ
HGNC:3431 ⓘ UniProt:P21860 ⓘ |
| encodes |
Receptor tyrosine-protein kinase erbB-3
ⓘ
linked to:
ERBB3
|
| expressedIn |
epithelial tissues
ⓘ
gastrointestinal tract ⓘ lung tissue ⓘ mammary gland ⓘ |
| formsHeterodimerWith |
EGFR (ERBB1)
ⓘ
linked to:
EGFR
ERBB2 (HER2) ⓘ
linked to:
ERBB2
ERBB4 ⓘ |
| hasBiologicalProcess |
MAPK signaling pathway
ⓘ
PI3K-AKT signaling pathway ⓘ cell differentiation ⓘ cell proliferation ⓘ cell survival ⓘ epithelial cell development ⓘ mammary gland development ⓘ signal transduction ⓘ |
| hasCellularComponent |
cell surface
ⓘ
integral component of membrane ⓘ plasma membrane ⓘ |
| hasDomain |
extracellular ligand-binding domain
ⓘ
intracellular tyrosine kinase-like domain ⓘ multiple tyrosine phosphorylation sites ⓘ single-pass transmembrane domain ⓘ |
| hasMolecularFunction |
neuregulin binding
ⓘ
protein tyrosine kinase activity (impaired intrinsic kinase) ⓘ receptor activity ⓘ |
| isDrugTarget |
monoclonal antibodies against HER3
ⓘ
pan-ErbB inhibitors ⓘ |
| locatedOnChromosome | human chromosome 12q13 ⓘ |
| organism | Homo sapiens ⓘ |
| postTranslationalModification |
glycosylation
ⓘ
tyrosine phosphorylation ⓘ |
| regulatedBy |
ligand-induced dimerization
ⓘ
receptor internalization and degradation ⓘ |
| roleInCancer |
contributes to therapy resistance
ⓘ
oncogenic signaling mediator ⓘ promotes tumor cell proliferation ⓘ promotes tumor cell survival ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: ERBB3 Description of subject: ERBB3 is a member of the ErbB family of receptor tyrosine kinases that plays a key role in cell signaling, particularly in cancer, often through potent mitogenic and survival pathways.
Referenced by (9)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: ERBB3
linked to: ERBB3
linked to: ERBB3