BCRP

E241383

ATP-binding cassette transporter drug transporter efflux transporter membrane protein multidrug resistance protein

BCRP (Breast Cancer Resistance Protein) is an ATP-binding cassette (ABC) efflux transporter involved in multidrug resistance and the transport of various drugs and xenobiotics across cellular membranes.

Try in SPARQL Jump to: Surface forms Disambiguation Statements Elicitation Referenced by

All labels observed (6)

Label	Occurrences
ABCG2	1
ATP-binding cassette sub-family G member 2	1
ATP-binding cassette transporter family	1
BCRP canonical	1
Breast Cancer Resistance Protein	1
breast cancer resistance protein	1

How this entity was disambiguated

This entity first appeared as the object of triple T2190671 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.

NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07

Target entity: BCRP
Context triple: [Xarelto, isSubstrateOf, BCRP]

A. BCRP
BCRP is the Central Reserve Bank of Peru, the country’s monetary authority responsible for maintaining monetary stability and managing its currency and international reserves.
B. BRC
BRC is the commonly used abbreviation for Black Rock City, the temporary city built annually in Nevada’s Black Rock Desert for the Burning Man festival.
C. BRC
BRC is the IATA airport code for San Carlos de Bariloche’s main international airport in Argentina.
D. BCRI
BCRI is a cultural and educational institution in Birmingham, Alabama that documents and promotes understanding of the American civil rights movement and ongoing struggles for human rights.
E. BCH
BCH is a leading pediatric medical center and teaching hospital in Boston renowned for its specialized care for children and groundbreaking research.
F. None of above. chosen
G. Unsure - the case is ambiguous/there is not enough information to decide.

NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07

Target entity: BCRP
Target entity description: BCRP (Breast Cancer Resistance Protein) is an ATP-binding cassette (ABC) efflux transporter involved in multidrug resistance and the transport of various drugs and xenobiotics across cellular membranes.

A. BCRP
BCRP is the Central Reserve Bank of Peru, the country’s monetary authority responsible for maintaining monetary stability and managing its currency and international reserves.
B. BRC
BRC is the commonly used abbreviation for Black Rock City, the temporary city built annually in Nevada’s Black Rock Desert for the Burning Man festival.
C. BRC
BRC is the IATA airport code for San Carlos de Bariloche’s main international airport in Argentina.
D. BCRI
BCRI is a cultural and educational institution in Birmingham, Alabama that documents and promotes understanding of the American civil rights movement and ongoing struggles for human rights.
E. BCH
BCH is a leading pediatric medical center and teaching hospital in Boston renowned for its specialized care for children and groundbreaking research.
F. None of above. chosen

Statements (52)

Predicate	Object
instanceOf	ATP-binding cassette transporter ⓘ drug transporter ⓘ efflux transporter ⓘ membrane protein ⓘ multidrug resistance protein ⓘ
alsoKnownAs	BCRP ⓘ surface form: ABCG2 BCRP ⓘ surface form: ATP-binding cassette sub-family G member 2 BCRP ⓘ surface form: Breast Cancer Resistance Protein
associatedWith	chemotherapy resistance ⓘ gout susceptibility via urate transport ⓘ reduced intracellular drug accumulation ⓘ
belongsToFamily	BCRP self-linksurface differs ⓘ surface form: ATP-binding cassette transporter family
belongsToSubfamily	ABC subfamily G ⓘ
biologicalRole	contribution to pharmacokinetic variability ⓘ efflux of drugs ⓘ efflux of xenobiotics ⓘ limitation of oral drug absorption ⓘ modulation of drug disposition ⓘ multidrug resistance in cancer cells ⓘ protection of tissues from toxic compounds ⓘ
containsDomain	nucleotide-binding domain ⓘ
effectOfPolymorphism	altered drug pharmacokinetics ⓘ altered transporter expression ⓘ
encodedBy	ABCG2 gene ⓘ
inhibitedBy	Ko143 ⓘ cyclosporine A ⓘ elacridar ⓘ tyrosine kinase inhibitors ⓘ
localization	apical membrane of epithelial cells ⓘ blood–brain barrier endothelial cells ⓘ hematopoietic stem cells ⓘ intestinal epithelium ⓘ kidney proximal tubule epithelium ⓘ liver canalicular membrane ⓘ placental syncytiotrophoblast ⓘ plasma membrane ⓘ
organism	Homo sapiens ⓘ
polymorphism	ABCG2 c.421C>A (Q141K) ⓘ
structure	half-transporter requiring homodimerization ⓘ
substrateOf	estrone-3-sulfate ⓘ fluoroquinolone antibiotics ⓘ imatinib ⓘ irinotecan and its metabolites ⓘ methotrexate ⓘ mitoxantrone ⓘ rosuvastatin ⓘ sulfasalazine ⓘ topotecan ⓘ uric acid ⓘ
topology	six transmembrane helices per monomer ⓘ
transportMechanism	ATP-dependent efflux ⓘ
usesEnergyFrom	ATP hydrolysis ⓘ

How these facts were elicited

Referenced by (6)

Full triples — surface form annotated when it differs from this entity's canonical label.

Xarelto → isSubstrateOf → BCRP ⓘ

BCRP → alsoKnownAs → BCRP ⓘ

this entity surface form: Breast Cancer Resistance Protein

BCRP → alsoKnownAs → BCRP ⓘ

this entity surface form: ABCG2

BCRP → alsoKnownAs → BCRP ⓘ

this entity surface form: ATP-binding cassette sub-family G member 2

BCRP → belongsToFamily → BCRP self-linksurface differs ⓘ

this entity surface form: ATP-binding cassette transporter family

apixaban → substrateOf → BCRP ⓘ

this entity surface form: breast cancer resistance protein

All labels observed (6)

How this entity was disambiguated Show

Statements (52)

How these facts were elicited Show

Referenced by (6)

How this entity was disambiguated

How these facts were elicited