CYP2J2
E242413
CYP2J2 is a human cytochrome P450 enzyme primarily expressed in the heart and other tissues, involved in the metabolism of various drugs and endogenous fatty acids.
All labels observed (4)
| Label | Occurrences |
|---|---|
| CYP2J2 canonical | 2 |
| CYP2J2 gene | 1 |
| CYP2J2*7 | 1 |
| cytochrome P450, family 2, subfamily J, polypeptide 2 | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T2190669 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: CYP2J2 Context triple: [Xarelto, isMetabolizedBy, CYP2J2]
-
A.
BCRP
BCRP is the Central Reserve Bank of Peru, the country’s monetary authority responsible for maintaining monetary stability and managing its currency and international reserves.
-
B.
CYP
CYP is the three-letter ISO 3166-1 alpha-3 country code assigned to Cyprus.
-
C.
JES2
JES2 (Job Entry Subsystem 2) is an IBM mainframe component that manages the input, scheduling, and output of batch jobs and print workloads in the z/OS operating system.
-
D.
Corachol
Corachol is a subfamily of Uto-Aztecan languages that includes closely related indigenous languages spoken in western Mexico.
-
E.
Activase
Activase is a brand-name form of the clot-dissolving drug alteplase, widely used as a thrombolytic treatment for acute ischemic stroke and certain types of heart attack and pulmonary embolism.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: CYP2J2 Target entity description: CYP2J2 is a human cytochrome P450 enzyme primarily expressed in the heart and other tissues, involved in the metabolism of various drugs and endogenous fatty acids.
-
A.
BCRP
BCRP is the Central Reserve Bank of Peru, the country’s monetary authority responsible for maintaining monetary stability and managing its currency and international reserves.
-
B.
CYP
CYP is the three-letter ISO 3166-1 alpha-3 country code assigned to Cyprus.
-
C.
JES2
JES2 (Job Entry Subsystem 2) is an IBM mainframe component that manages the input, scheduling, and output of batch jobs and print workloads in the z/OS operating system.
-
D.
Corachol
Corachol is a subfamily of Uto-Aztecan languages that includes closely related indigenous languages spoken in western Mexico.
-
E.
Activase
Activase is a brand-name form of the clot-dissolving drug alteplase, widely used as a thrombolytic treatment for acute ischemic stroke and certain types of heart attack and pulmonary embolism.
- F. None of above. chosen
Statements (68)
| Predicate | Object |
|---|---|
| instanceOf |
cytochrome P450 enzyme
ⓘ
drug-metabolizing enzyme ⓘ monooxygenase ⓘ protein-coding gene ⓘ |
| alias |
CYP2J2
ⓘ
surface form:
CYP2J2 gene
CYP2J2 ⓘ
surface form:
cytochrome P450, family 2, subfamily J, polypeptide 2
|
| associatedWith |
anti-inflammatory effects via EETs
ⓘ
cardioprotection ⓘ cardiovascular homeostasis ⓘ regulation of vascular tone ⓘ |
| biologicalProcess |
arachidonic acid metabolic process
ⓘ
drug metabolic process ⓘ epoxyeicosatrienoic acid biosynthetic process ⓘ epoxygenase P450 pathway ⓘ xenobiotic metabolic process ⓘ |
| cellularLocation | endoplasmic reticulum ⓘ |
| clinicalRelevance |
interindividual variability in drug response
ⓘ
potential association with coronary artery disease risk ⓘ |
| cofactor | heme ⓘ |
| CYPFamily | CYP2 ⓘ |
| CYPMember | 2 ⓘ |
| CYPSubfamily | J ⓘ |
| encodes | cytochrome P450 2J2 ⓘ |
| enzymeCommissionNumber | 1.14.14.1 ⓘ |
| expressedIn |
brain
ⓘ
endothelium ⓘ heart ⓘ kidney ⓘ liver ⓘ lung ⓘ pancreas ⓘ skeletal muscle ⓘ small intestine ⓘ testis ⓘ |
| foundInTaxon | Homo sapiens ⓘ |
| geneSymbol | CYP2J2 self-link ⓘ |
| inhibitedBy |
danazol
ⓘ
fluconazole ⓘ grapefruit juice components ⓘ itraconazole ⓘ ketoconazole ⓘ |
| locatedIn |
1p31.3
ⓘ
chromosome 1 ⓘ |
| metabolizes |
albendazole
ⓘ
amiodarone ⓘ astemizole ⓘ cisapride ⓘ doxorubicin ⓘ ebastine ⓘ ritonavir ⓘ terfenadine ⓘ |
| molecularFunction |
arachidonic acid monooxygenase activity
ⓘ
epoxygenase activity ⓘ heme binding ⓘ iron ion binding ⓘ oxidoreductase activity ⓘ |
| pathway |
arachidonic acid epoxygenase pathway
ⓘ
drug metabolism by cytochrome P450 ⓘ |
| polymorphism |
CYP2J2
self-linksurface differs
ⓘ
surface form:
CYP2J2*7
|
| product |
epoxyeicosatrienoic acids
ⓘ
epoxyoctadecenoic acids ⓘ |
| requires |
NADPH
ⓘ
cytochrome P450 reductase ⓘ |
| substrate |
arachidonic acid
ⓘ
docosahexaenoic acid ⓘ eicosapentaenoic acid ⓘ linoleic acid ⓘ |
| uniprotId | P51589 ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: CYP2J2 Description of subject: CYP2J2 is a human cytochrome P450 enzyme primarily expressed in the heart and other tissues, involved in the metabolism of various drugs and endogenous fatty acids.
Referenced by (5)
Full triples — surface form annotated when it differs from this entity's canonical label.
this entity surface form:
CYP2J2*7
this entity surface form:
cytochrome P450, family 2, subfamily J, polypeptide 2