SMCR8-WDR41 complex
E561102
The SMCR8-WDR41 complex is a protein assembly that partners with C9orf72 to regulate autophagy and lysosomal function, particularly in the context of neurodegenerative disease mechanisms.
All labels observed (4)
| Label | Occurrences |
|---|---|
| C9orf72–SMCR8–WDR41 complex | 2 |
| SMCR8-C9orf72-WDR41 complex | 1 |
| SMCR8-WDR41 complex canonical | 1 |
| WD repeat domain 41 | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T6004834 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: SMCR8-WDR41 complex Context triple: [C9orf72, formsComplexWith, SMCR8-WDR41 complex]
-
A.
W3/W4/W5 complex
The W3/W4/W5 complex is a large, neighboring group of massive star-forming regions in the Perseus Arm of the Milky Way, notable for its active stellar nurseries and intricate nebular structures.
-
B.
TARDBP
TARDBP is a gene encoding the TDP-43 protein, a DNA/RNA-binding protein whose abnormal aggregation is a key pathological feature in amyotrophic lateral sclerosis and related neurodegenerative diseases.
-
C.
The O2 complex
The O2 complex is a large entertainment district in London featuring the O2 Arena, cinemas, restaurants, bars, and various leisure and retail facilities housed under the iconic dome structure.
-
D.
Cdc28
Cdc28 is the major cyclin-dependent kinase in budding yeast that drives progression through the cell cycle by phosphorylating key regulatory proteins.
-
E.
CD38
CD38 is a cell surface glycoprotein with ectoenzyme and receptor functions, highly expressed on plasma cells and targeted in therapies for multiple myeloma and other hematologic malignancies.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: SMCR8-WDR41 complex Target entity description: The SMCR8-WDR41 complex is a protein assembly that partners with C9orf72 to regulate autophagy and lysosomal function, particularly in the context of neurodegenerative disease mechanisms.
-
A.
W3/W4/W5 complex
The W3/W4/W5 complex is a large, neighboring group of massive star-forming regions in the Perseus Arm of the Milky Way, notable for its active stellar nurseries and intricate nebular structures.
-
B.
TARDBP
TARDBP is a gene encoding the TDP-43 protein, a DNA/RNA-binding protein whose abnormal aggregation is a key pathological feature in amyotrophic lateral sclerosis and related neurodegenerative diseases.
-
C.
The O2 complex
The O2 complex is a large entertainment district in London featuring the O2 Arena, cinemas, restaurants, bars, and various leisure and retail facilities housed under the iconic dome structure.
-
D.
Cdc28
Cdc28 is the major cyclin-dependent kinase in budding yeast that drives progression through the cell cycle by phosphorylating key regulatory proteins.
-
E.
CD38
CD38 is a cell surface glycoprotein with ectoenzyme and receptor functions, highly expressed on plasma cells and targeted in therapies for multiple myeloma and other hematologic malignancies.
- F. None of above. chosen
Statements (35)
| Predicate | Object |
|---|---|
| instanceOf |
macromolecular complex
ⓘ
protein complex ⓘ |
| associatedWith |
C9orf72-related neurodegeneration
ⓘ
amyotrophic lateral sclerosis ⓘ frontotemporal dementia ⓘ neurodegenerative disease mechanisms ⓘ |
| binds |
C9orf72 protein
ⓘ
linked to:
C9orf72
|
| disruptionLeadsTo |
abnormal lysosomal morphology
ⓘ
accumulation of autophagic substrates ⓘ impaired autophagy ⓘ |
| formsComplexWith |
C9orf72 protein
ⓘ
linked to:
C9orf72
|
| hasFunction |
regulator of small GTPase signaling
ⓘ
scaffold for C9orf72 ⓘ |
| hasPart |
SMCR8 protein
ⓘ
linked to:
SMCR8
WDR41 protein ⓘ |
| interactsWith |
Rab GTPases
ⓘ
autophagy machinery components ⓘ |
| involvedIn |
cellular response to nutrient status
ⓘ
protein degradation pathways ⓘ |
| isAffectedBy | C9orf72 hexanucleotide repeat expansion ⓘ |
| isComponentOf |
C9orf72–SMCR8–WDR41 complex
ⓘ
linked to:
SMCR8-WDR41 complex
|
| localizesTo |
cytoplasm
ⓘ
late endosome ⓘ lysosome ⓘ |
| participatesIn |
autophagosome–lysosome fusion regulation
ⓘ
autophagy regulation ⓘ lysosomal function regulation ⓘ lysosome homeostasis ⓘ |
| regulates |
TFEB activity
ⓘ
autophagic flux ⓘ lysosomal biogenesis ⓘ lysosomal trafficking ⓘ mTORC1 signaling at lysosomes ⓘ |
| studiedIn |
mouse models of C9orf72 deficiency
ⓘ
neuronal cells ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: SMCR8-WDR41 complex Description of subject: The SMCR8-WDR41 complex is a protein assembly that partners with C9orf72 to regulate autophagy and lysosomal function, particularly in the context of neurodegenerative disease mechanisms.
Referenced by (5)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: SMCR8-WDR41 complex
linked to: SMCR8-WDR41 complex
linked to: SMCR8-WDR41 complex
subject linked to:
chromosome 9 open reading frame 72
linked to: SMCR8-WDR41 complex