Triple

T6004834
Position Surface form Disambiguated ID Type / Status
Subject C9orf72 E133683 entity
Predicate formsComplexWith P6653 FINISHED
Object SMCR8-WDR41 complex
The SMCR8-WDR41 complex is a protein assembly that partners with C9orf72 to regulate autophagy and lysosomal function, particularly in the context of neurodegenerative disease mechanisms.
E561102 NE FINISHED

How this triple was built (4 steps)

Every LLM step that produced this triple, in pipeline order — named-entity classification, the disambiguation choices (the exact options shown, with the pick highlighted), and the generated description. The batch + timestamp of each is in the Provenance table below.

NER Named-entity recognition gpt-5-mini
Instruction
Given a phrase, classify it is english named entity (e.g., persons, organizations, works of art) in Latin script, or not (e.g., literals, dates, URLs, verbose phrases). For disambiguation, the statement where the phrase occurs as object is also given. Please return a JSON object with `phrase` (string, the phrase being analyzed) and `is_ne` (boolean, indicating whether the phrase is a Named Entity).
Input
Phrase: SMCR8-WDR41 complex | Statement: [C9orf72, formsComplexWith, SMCR8-WDR41 complex]
NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07
Target entity: SMCR8-WDR41 complex
Context triple: [C9orf72, formsComplexWith, SMCR8-WDR41 complex]
  • A. W3/W4/W5 complex
    The W3/W4/W5 complex is a large, neighboring group of massive star-forming regions in the Perseus Arm of the Milky Way, notable for its active stellar nurseries and intricate nebular structures.
  • B. TARDBP
    TARDBP is a gene encoding the TDP-43 protein, a DNA/RNA-binding protein whose abnormal aggregation is a key pathological feature in amyotrophic lateral sclerosis and related neurodegenerative diseases.
  • C. The O2 complex
    The O2 complex is a large entertainment district in London featuring the O2 Arena, cinemas, restaurants, bars, and various leisure and retail facilities housed under the iconic dome structure.
  • D. Cdc28
    Cdc28 is the major cyclin-dependent kinase in budding yeast that drives progression through the cell cycle by phosphorylating key regulatory proteins.
  • E. CD38
    CD38 is a cell surface glycoprotein with ectoenzyme and receptor functions, highly expressed on plasma cells and targeted in therapies for multiple myeloma and other hematologic malignancies.
  • F. None of above. chosen
  • G. Unsure - the case is ambiguous/there is not enough information to decide.
NEDg Description generation gpt-5.1
Instruction
Generate a one-sentence description of the target entity. 
You are given a context triple in the form (subject, predicate, object), where the object is the target entity. 
# Instructions
Use the triple to infer relevant information about the entity. Describe the entity based on what is most defining, well-known. 
Avoid repeating the information from the triple, unless really essential.
# Response Format
Return only the sentence: "Description: [one-sentence description of the target entity]"
Input
Entity: SMCR8-WDR41 complex
Triple: [C9orf72, formsComplexWith, SMCR8-WDR41 complex]
Generated description
The SMCR8-WDR41 complex is a protein assembly that partners with C9orf72 to regulate autophagy and lysosomal function, particularly in the context of neurodegenerative disease mechanisms.
NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07
Target entity: SMCR8-WDR41 complex
Target entity description: The SMCR8-WDR41 complex is a protein assembly that partners with C9orf72 to regulate autophagy and lysosomal function, particularly in the context of neurodegenerative disease mechanisms.
  • A. W3/W4/W5 complex
    The W3/W4/W5 complex is a large, neighboring group of massive star-forming regions in the Perseus Arm of the Milky Way, notable for its active stellar nurseries and intricate nebular structures.
  • B. TARDBP
    TARDBP is a gene encoding the TDP-43 protein, a DNA/RNA-binding protein whose abnormal aggregation is a key pathological feature in amyotrophic lateral sclerosis and related neurodegenerative diseases.
  • C. The O2 complex
    The O2 complex is a large entertainment district in London featuring the O2 Arena, cinemas, restaurants, bars, and various leisure and retail facilities housed under the iconic dome structure.
  • D. Cdc28
    Cdc28 is the major cyclin-dependent kinase in budding yeast that drives progression through the cell cycle by phosphorylating key regulatory proteins.
  • E. CD38
    CD38 is a cell surface glycoprotein with ectoenzyme and receptor functions, highly expressed on plasma cells and targeted in therapies for multiple myeloma and other hematologic malignancies.
  • F. None of above. chosen

Provenance (5 batches)

The batch behind each pipeline step, in order, with when it ran. Timestamps are batch-level — stages were processed in waves, so the object chain (NER → NED1 → NEDg → NED2) reads in order, but predicate / elicitation batches can sit in a different wave.

Step Stage Batch ID Status When
creating Elicitation batch_69c00872444c8190bfaf1739dcec765c completed March 22, 2026, 3:19 p.m.
NER Named-entity recognition batch_69c04f10d18081908c351170b7f58d3d completed March 22, 2026, 8:20 p.m.
NED1 Entity disambiguation (via context triple) batch_69c1088f5c84819094e4696c24c4dd79 completed March 23, 2026, 9:31 a.m.
NEDg Description generation batch_69c1099f00f88190a5f1f0fafbb679c2 completed March 23, 2026, 9:36 a.m.
NED2 Entity disambiguation (via description) batch_69c10a2ffdcc8190bfeebc59d98b2b29 completed March 23, 2026, 9:38 a.m.
Created at: March 22, 2026, 4:06 p.m.