IL-17A
E561033
IL-17A is a pro-inflammatory cytokine produced mainly by Th17 cells that plays a key role in the pathogenesis of several autoimmune and inflammatory diseases.
All labels observed (3)
| Label | Occurrences |
|---|---|
| IL-17 cytokine family | 1 |
| IL-17A canonical | 1 |
| IL17A gene | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T6003570 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: IL-17A Context triple: [Taltz, targets, IL-17A]
-
A.
IN-2
IN-2 is the standard postal-style abbreviation used to refer to Indiana's 2nd congressional district in the U.S. House of Representatives.
-
B.
TNF
TNF is a weekly National Football League (NFL) primetime broadcast package featuring games played on Thursday nights during the regular season.
-
C.
Bruton tyrosine kinase
Bruton tyrosine kinase is a key signaling enzyme in B cells that plays a crucial role in their development and function and is a major therapeutic target in certain blood cancers and autoimmune diseases.
-
D.
programmed death-ligand 1
Programmed death-ligand 1 (PD-L1) is an immune checkpoint protein expressed on various cells that suppresses T-cell activity by engaging PD-1, enabling tumors to evade immune surveillance.
-
E.
CD20 protein
CD20 protein is a cell-surface antigen found primarily on B lymphocytes and is a key therapeutic target in certain autoimmune diseases and B-cell malignancies.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: IL-17A Target entity description: IL-17A is a pro-inflammatory cytokine produced mainly by Th17 cells that plays a key role in the pathogenesis of several autoimmune and inflammatory diseases.
-
A.
IN-2
IN-2 is the standard postal-style abbreviation used to refer to Indiana's 2nd congressional district in the U.S. House of Representatives.
-
B.
TNF
TNF is a weekly National Football League (NFL) primetime broadcast package featuring games played on Thursday nights during the regular season.
-
C.
Bruton tyrosine kinase
Bruton tyrosine kinase is a key signaling enzyme in B cells that plays a crucial role in their development and function and is a major therapeutic target in certain blood cancers and autoimmune diseases.
-
D.
programmed death-ligand 1
Programmed death-ligand 1 (PD-L1) is an immune checkpoint protein expressed on various cells that suppresses T-cell activity by engaging PD-1, enabling tumors to evade immune surveillance.
-
E.
CD20 protein
CD20 protein is a cell-surface antigen found primarily on B lymphocytes and is a key therapeutic target in certain autoimmune diseases and B-cell malignancies.
- F. None of above. chosen
Statements (56)
| Predicate | Object |
|---|---|
| instanceOf |
cytokine
ⓘ
interleukin ⓘ pro-inflammatory cytokine ⓘ protein ⓘ |
| activatesPathway |
C/EBP signaling pathway
ⓘ
MAPK signaling pathway ⓘ NF-κB signaling pathway ⓘ |
| alternativeName |
CTLA-8
ⓘ
interleukin-17A ⓘ |
| associatedWithDisease |
Crohn's disease
ⓘ
ankylosing spondylitis ⓘ asthma ⓘ autoimmune disease ⓘ chronic inflammatory disease ⓘ inflammatory bowel disease ⓘ multiple sclerosis ⓘ psoriasis ⓘ psoriatic arthritis ⓘ rheumatoid arthritis ⓘ systemic lupus erythematosus ⓘ ulcerative colitis ⓘ |
| belongsToFamily |
IL-17 cytokine family
ⓘ
linked to:
IL-17A
|
| bindsTo |
IL-17 receptor complex
ⓘ
linked to:
IL-17RA
|
| chromosomalLocationOfGene | human chromosome 6p12 ⓘ |
| downregulatedBy |
IFN-γ
ⓘ
IL-27 ⓘ IL-4 ⓘ |
| encodedBy |
IL17A gene
ⓘ
linked to:
IL-17A
|
| expressedByTissue |
inflamed synovium
ⓘ
psoriatic skin lesion ⓘ |
| formsHeterodimer | IL-17A/F heterodimer ⓘ |
| formsHomodimer | IL-17A homodimer ⓘ |
| formsReceptorComplexWith | IL-17RA–IL-17RC heterodimer ⓘ |
| induces |
G-CSF production
ⓘ
antimicrobial peptide production ⓘ chemokine production ⓘ neutrophil recruitment ⓘ pro-inflammatory cytokine production ⓘ |
| producedByCellType |
CD4-positive T cell
ⓘ
CD8-positive T cell ⓘ
linked to:
CD8+ T cells
NK cell ⓘ Th17 cell ⓘ innate lymphoid cell ⓘ mast cell ⓘ neutrophil ⓘ γδ T cell ⓘ |
| receptor |
IL-17RA
ⓘ
IL-17RC ⓘ |
| roleInProcess |
host defense against extracellular bacteria
ⓘ
host defense against fungi ⓘ |
| secretedBy | activated Th17 cell ⓘ |
| therapeuticTargetOf |
ixekizumab
ⓘ
linked to:
Taltz
netakimab ⓘ secukinumab ⓘ
linked to:
Cosentyx
|
| upregulatedBy |
IL-23
ⓘ
TGF-β plus IL-6 ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: IL-17A Description of subject: IL-17A is a pro-inflammatory cytokine produced mainly by Th17 cells that plays a key role in the pathogenesis of several autoimmune and inflammatory diseases.
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.