CTLA-8
E1549324
UNEXPLORED
CTLA-8 is an early designation for interleukin-17A (IL-17A), a pro-inflammatory cytokine produced mainly by Th17 cells that plays a key role in immune responses and inflammatory diseases.
All labels observed (1)
| Label | Occurrences |
|---|---|
| CTLA-8 canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T22690336 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: CTLA-8 Context triple: [IL-17A, alternativeName, CTLA-8]
-
A.
B7-H1
B7-H1, also known as PD-L1, is an immune checkpoint protein expressed on various cells that modulates T-cell activity and is targeted by certain cancer immunotherapies.
-
B.
CD3 complex
The CD3 complex is a multi-subunit protein complex associated with the T-cell receptor that is essential for T-cell activation and signal transduction in the immune system.
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C.
CD22
CD22 is a B-cell–specific surface glycoprotein that functions as an inhibitory co-receptor modulating B cell receptor signaling and immune responses.
-
D.
IL-64
IL-64 is a major east–west state highway in Illinois that runs from the Mississippi River through the Chicago metropolitan area.
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E.
programmed cell death protein 1
Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor on T cells that downregulates immune responses and promotes self-tolerance, making it a key target in cancer immunotherapy.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: CTLA-8 Target entity description: CTLA-8 is an early designation for interleukin-17A (IL-17A), a pro-inflammatory cytokine produced mainly by Th17 cells that plays a key role in immune responses and inflammatory diseases.
-
A.
B7-H1
B7-H1, also known as PD-L1, is an immune checkpoint protein expressed on various cells that modulates T-cell activity and is targeted by certain cancer immunotherapies.
-
B.
CD3 complex
The CD3 complex is a multi-subunit protein complex associated with the T-cell receptor that is essential for T-cell activation and signal transduction in the immune system.
-
C.
CD22
CD22 is a B-cell–specific surface glycoprotein that functions as an inhibitory co-receptor modulating B cell receptor signaling and immune responses.
-
D.
IL-64
IL-64 is a major east–west state highway in Illinois that runs from the Mississippi River through the Chicago metropolitan area.
-
E.
programmed cell death protein 1
Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor on T cells that downregulates immune responses and promotes self-tolerance, making it a key target in cancer immunotherapy.
- F. None of above. chosen
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.