MAPK signaling pathway
E902874
The MAPK signaling pathway is a key intracellular cascade that transmits growth and survival signals from cell surface receptors to the nucleus, regulating processes such as proliferation, differentiation, and apoptosis.
All labels observed (2)
| Label | Occurrences |
|---|---|
| MAPK signaling pathway canonical | 5 |
| RAS-RAF-MEK-ERK signaling pathway | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T11074236 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: MAPK signaling pathway Context triple: [HER2 receptor, activatesPathway, MAPK signaling pathway]
-
A.
Reactome pathways
Reactome pathways are curated, peer-reviewed biological pathways that map molecular interactions and processes in human biology and other species.
-
B.
KEGG pathways
KEGG pathways are curated biological pathway maps in the KEGG database that represent networks of molecular interactions, reactions, and relations involved in cellular and organismal processes.
-
C.
Toll-like receptor signaling pathway
The Toll-like receptor signaling pathway is a key innate immune signaling cascade that detects pathogen-associated molecular patterns and activates downstream inflammatory and antiviral responses.
-
D.
ERK
ERK is the abbreviation for the Evangelical Reformed Church, a Protestant regional church within the Reformed tradition.
-
E.
Src family kinases
Src family kinases are a group of non-receptor tyrosine kinases that regulate key cellular processes such as proliferation, differentiation, survival, and migration, and are often implicated in cancer and immune signaling.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: MAPK signaling pathway Target entity description: The MAPK signaling pathway is a key intracellular cascade that transmits growth and survival signals from cell surface receptors to the nucleus, regulating processes such as proliferation, differentiation, and apoptosis.
-
A.
Reactome pathways
Reactome pathways are curated, peer-reviewed biological pathways that map molecular interactions and processes in human biology and other species.
-
B.
KEGG pathways
KEGG pathways are curated biological pathway maps in the KEGG database that represent networks of molecular interactions, reactions, and relations involved in cellular and organismal processes.
-
C.
Toll-like receptor signaling pathway
The Toll-like receptor signaling pathway is a key innate immune signaling cascade that detects pathogen-associated molecular patterns and activates downstream inflammatory and antiviral responses.
-
D.
ERK
ERK is the abbreviation for the Evangelical Reformed Church, a Protestant regional church within the Reformed tradition.
-
E.
Src family kinases
Src family kinases are a group of non-receptor tyrosine kinases that regulate key cellular processes such as proliferation, differentiation, survival, and migration, and are often implicated in cancer and immune signaling.
- F. None of above. chosen
Statements (51)
| Predicate | Object |
|---|---|
| instanceOf |
intracellular signaling cascade
ⓘ
signal transduction pathway ⓘ |
| activatedBy |
G protein–coupled receptors
ⓘ
cytokine receptors ⓘ growth factors ⓘ integrins ⓘ mitogens ⓘ receptor tyrosine kinases ⓘ stress stimuli ⓘ |
| associatedWith |
cancer
ⓘ
cardiovascular diseases ⓘ inflammatory diseases ⓘ neurodegenerative diseases ⓘ |
| conservedIn |
eukaryotes
ⓘ
mammals ⓘ yeast ⓘ |
| hasComponent |
ERK kinase
ⓘ
linked to:
ERK
JNK kinase ⓘ
linked to:
JNK
MAPK phosphatases ⓘ MEK kinase ⓘ Raf kinase ⓘ Ras protein ⓘ p38 MAPK ⓘ scaffold proteins ⓘ |
| hasSubPathway |
ERK1/2 pathway
ⓘ
ERK5 pathway ⓘ
linked to:
ERK
JNK pathway ⓘ p38 MAPK pathway ⓘ |
| negativelyRegulatedBy |
MAPK phosphatases
ⓘ
Sprouty proteins ⓘ protein phosphatase 2A ⓘ |
| occursIn |
cell nucleus
ⓘ
cytoplasm ⓘ plasma membrane ⓘ |
| phosphorylates |
cytoskeletal proteins
ⓘ
other kinases ⓘ transcription factors ⓘ |
| regulates |
apoptosis
ⓘ
cell cycle progression ⓘ cell differentiation ⓘ cell proliferation ⓘ cell survival ⓘ developmental processes ⓘ differentiation of immune cells ⓘ gene expression ⓘ inflammatory responses ⓘ neuronal plasticity ⓘ stress responses ⓘ |
| targetOf | small molecule kinase inhibitors ⓘ |
| transmitsSignalFrom | cell surface receptors ⓘ |
| transmitsSignalTo | nuclear transcription factors ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: MAPK signaling pathway Description of subject: The MAPK signaling pathway is a key intracellular cascade that transmits growth and survival signals from cell surface receptors to the nucleus, regulating processes such as proliferation, differentiation, and apoptosis.
Referenced by (6)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject linked to:
INS gene in humans
subject linked to:
vascular endothelial growth factor A
linked to: MAPK signaling pathway