NMDA receptor
E494104
The NMDA receptor is a glutamate-activated ion channel in the brain that plays a key role in synaptic plasticity, learning, and memory, and is implicated in various neurological and psychiatric disorders.
All labels observed (3)
| Label | Occurrences |
|---|---|
| NMDA receptor canonical | 2 |
| GluN1 | 1 |
| NMDA receptors | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T5114894 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: NMDA receptor Context triple: [Memantine, targets, NMDA receptor]
-
A.
memantine
Memantine is a medication that helps manage symptoms of moderate to severe Alzheimer's disease by modulating glutamate activity in the brain.
-
B.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
-
C.
hippocampus
The hippocampus is a key brain structure involved in forming and retrieving memories, spatial navigation, and regulating emotional responses.
-
D.
CB2 receptor
The CB2 receptor is a cannabinoid receptor primarily expressed in immune and peripheral tissues, where it modulates inflammation and immune responses and serves as a key target of compounds like THC.
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E.
Hodgkin–Huxley model
The Hodgkin–Huxley model is a mathematical description of how action potentials in neurons are initiated and propagated through voltage-gated ion channels in the cell membrane.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: NMDA receptor Target entity description: The NMDA receptor is a glutamate-activated ion channel in the brain that plays a key role in synaptic plasticity, learning, and memory, and is implicated in various neurological and psychiatric disorders.
-
A.
memantine
Memantine is a medication that helps manage symptoms of moderate to severe Alzheimer's disease by modulating glutamate activity in the brain.
-
B.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
-
C.
hippocampus
The hippocampus is a key brain structure involved in forming and retrieving memories, spatial navigation, and regulating emotional responses.
-
D.
CB2 receptor
The CB2 receptor is a cannabinoid receptor primarily expressed in immune and peripheral tissues, where it modulates inflammation and immune responses and serves as a key target of compounds like THC.
-
E.
Hodgkin–Huxley model
The Hodgkin–Huxley model is a mathematical description of how action potentials in neurons are initiated and propagated through voltage-gated ion channels in the cell membrane.
- F. None of above. chosen
Statements (69)
| Predicate | Object |
|---|---|
| instanceOf |
ionotropic glutamate receptor
ⓘ
ligand-gated ion channel ⓘ membrane protein complex ⓘ |
| activatedBy |
N-methyl-D-aspartate
ⓘ
glutamate ⓘ |
| belongsTo | glutamatergic synapse pathway ⓘ |
| blockedBy | Mg2+ (voltage-dependent block) ⓘ |
| coAgonistRequired |
D-serine
ⓘ
glycine ⓘ |
| distinguishedFrom |
AMPA receptor
ⓘ
linked to:
AMPA receptors
kainate receptor ⓘ |
| downstreamEffect |
Ca2+-dependent signaling cascades
ⓘ
gene expression changes ⓘ |
| encodedBy |
GRIN1
ⓘ
GRIN2A ⓘ GRIN2B ⓘ GRIN2C ⓘ GRIN2D ⓘ GRIN3A ⓘ GRIN3B ⓘ |
| fullName | N-methyl-D-aspartate receptor ⓘ |
| hasDomain |
intracellular C-terminal domain
ⓘ
ion channel pore domain ⓘ ligand-binding domain ⓘ |
| hasFunction |
coincidence detection of presynaptic and postsynaptic activity
ⓘ
mediates excitatory synaptic transmission ⓘ mediates synaptic plasticity ⓘ supports long-term depression ⓘ supports long-term potentiation ⓘ |
| hasKinetics | slow activation and deactivation compared to AMPA receptors ⓘ |
| hasSubunit |
GluN1
ⓘ
linked to:
NMDA receptor
GluN2A ⓘ GluN2B ⓘ GluN2C ⓘ GluN2D ⓘ GluN3A ⓘ GluN3B ⓘ |
| implicatedIn |
Alzheimer's disease
ⓘ
Huntington's disease ⓘ
linked to:
Huntington's chorea
Parkinson's disease ⓘ epilepsy ⓘ major depressive disorder ⓘ schizophrenia ⓘ stroke ⓘ traumatic brain injury ⓘ |
| interactsWith |
CaMKII
ⓘ
PSD-95 ⓘ |
| involvedIn |
learning
ⓘ
memory formation ⓘ neural development ⓘ synaptogenesis ⓘ |
| locatedIn |
central nervous system
ⓘ
cerebral cortex ⓘ hippocampus ⓘ postsynaptic density ⓘ spinal cord ⓘ |
| modulatedBy |
polyamines
ⓘ
protons (pH) ⓘ zinc ⓘ |
| overactivationLeadsTo | excitotoxicity ⓘ |
| permeableTo |
Ca2+
ⓘ
K+ ⓘ Na+ ⓘ |
| pharmacologicallyBlockedBy |
MK-801
ⓘ
ketamine ⓘ memantine ⓘ phencyclidine ⓘ |
| requires |
extracellular glycine-binding site occupancy
ⓘ
membrane depolarization for full activation ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: NMDA receptor Description of subject: The NMDA receptor is a glutamate-activated ion channel in the brain that plays a key role in synaptic plasticity, learning, and memory, and is implicated in various neurological and psychiatric disorders.
Referenced by (4)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: NMDA receptor
linked to: NMDA receptor