GRIN3A

Target entity: GRIN3A
Context triple: [NMDA receptor, encodedBy, GRIN3A]

• A. GRIN1
  GRIN1 is a gene that encodes an essential subunit of NMDA-type glutamate receptors, which play a key role in synaptic transmission and plasticity in the central nervous system.
• B. GNAS
  GNAS is the abbreviation for the Georgian National Academy of Sciences, the leading scientific institution in Georgia that coordinates and promotes research across various disciplines.
• C. GNAI3 gene (for Gαi3 in humans)
  The GNAI3 gene encodes the Gαi3 alpha subunit of heterotrimeric G proteins in humans, a key regulator of inhibitory G protein–coupled receptor signaling pathways that modulate intracellular second messengers such as cAMP.
• D. SCN1A
  SCN1A is a human gene encoding a neuronal voltage-gated sodium channel alpha subunit whose mutations are a major cause of Dravet syndrome and other epilepsy disorders.
• E. HTT gene
  The HTT gene encodes the huntingtin protein, and mutations in this gene—particularly CAG trinucleotide repeat expansions—cause Huntington's disease, a progressive neurodegenerative disorder.
• F. None of above. chosen
• G. Unsure - the case is ambiguous/there is not enough information to decide.

Target entity: GRIN3A
Target entity description: GRIN3A is a gene that encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, a key glutamate-gated ion channel involved in synaptic transmission and plasticity in the central nervous system.

• A. GRIN1
  GRIN1 is a gene that encodes an essential subunit of NMDA-type glutamate receptors, which play a key role in synaptic transmission and plasticity in the central nervous system.
• B. GNAS
  GNAS is the abbreviation for the Georgian National Academy of Sciences, the leading scientific institution in Georgia that coordinates and promotes research across various disciplines.
• C. GNAI3 gene (for Gαi3 in humans)
  The GNAI3 gene encodes the Gαi3 alpha subunit of heterotrimeric G proteins in humans, a key regulator of inhibitory G protein–coupled receptor signaling pathways that modulate intracellular second messengers such as cAMP.
• D. SCN1A
  SCN1A is a human gene encoding a neuronal voltage-gated sodium channel alpha subunit whose mutations are a major cause of Dravet syndrome and other epilepsy disorders.
• E. HTT gene
  The HTT gene encodes the huntingtin protein, and mutations in this gene—particularly CAG trinucleotide repeat expansions—cause Huntington's disease, a progressive neurodegenerative disorder.
• F. None of above. chosen