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gptkbp:instanceOf
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gptkb:enzyme
|
|
gptkbp:alternativeName
|
EC 3.1.21.1
deoxyribonuclease I
pancreatic DNase
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gptkbp:CASNumber
|
9003-98-9
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gptkbp:cofactor
|
Mg2+
Ca2+
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gptkbp:discoveredBy
|
J. F. McCarthy
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gptkbp:discoveredIn
|
1946
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gptkbp:EC_number
|
3.1.21.1
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gptkbp:foundIn
|
pancreas
blood plasma
saliva
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gptkbp:function
|
catalyzes the hydrolysis of DNA
|
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gptkbp:gene
|
DNASE1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DNase I
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gptkbp:inhibitedBy
|
gptkb:actin
|
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gptkbp:medicalUse
|
reduces viscosity of mucus in lungs
|
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gptkbp:molecularWeight
|
~31 kDa
|
|
gptkbp:optimum_pH
|
37°C
7.0-8.0
|
|
gptkbp:PDB
|
2DNJ
|
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gptkbp:pharmaceutical_form
|
gptkb:dornase_alfa
|
|
gptkbp:product
|
oligonucleotides
|
|
gptkbp:species
|
gptkb:Bos_taurus
gptkb:Homo_sapiens
gptkb:Sus_scrofa
|
|
gptkbp:structure
|
monomeric protein
|
|
gptkbp:substrate
|
gptkb:gene
|
|
gptkbp:UniProtID
|
P24855
|
|
gptkbp:used_in
|
molecular biology
treatment of cystic fibrosis
|
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gptkbp:usedFor
|
chromatin accessibility assays
removal of DNA from RNA preparations
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gptkbp:bfsParent
|
gptkb:DNase
|
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gptkbp:bfsLayer
|
7
|