Statements (40)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
genomics technique
|
| gptkbp:alternativeTo |
MNase-Seq
|
| gptkbp:analyzes |
chromatin accessibility
|
| gptkbp:appliesTo |
epigenomics
cell type-specific chromatin profiling transcription factor binding site discovery |
| gptkbp:citation |
Song L, Crawford GE. Genome Res. 2010;20(2):171-9.
|
| gptkbp:detects |
insulators
silencers promoters enhancers regulatory DNA elements |
| gptkbp:developedBy |
2000s
|
| gptkbp:firstPublished |
John Stamatoyannopoulos lab
|
| gptkbp:hasBiologicalActivity |
gptkb:DNase_I
|
| https://www.w3.org/2000/01/rdf-schema#label |
DNase-Seq
|
| gptkbp:improves |
single-cell DNase-Seq
|
| gptkbp:limitation |
complex data analysis
requires large cell numbers sensitive to experimental conditions |
| gptkbp:relatedTo |
gptkb:ChIP-Seq
gptkb:ATAC-Seq FAIRE-Seq |
| gptkbp:requires |
next-generation sequencing
bioinformatics analysis |
| gptkbp:species |
gptkb:human
gptkb:mouse gptkb:Drosophila_melanogaster gptkb:Arabidopsis_thaliana |
| gptkbp:supportsProtocol |
high-throughput sequencing
DNA purification DNase I digestion |
| gptkbp:type |
sequencing reads
genome-wide maps |
| gptkbp:usedFor |
mapping open chromatin regions
studying gene regulation identifying DNase I hypersensitive sites |
| gptkbp:usedIn |
gptkb:ENCODE_project
|
| gptkbp:bfsParent |
gptkb:ChIP-Seq
|
| gptkbp:bfsLayer |
7
|