Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:activeSiteResidue |
conserved amino acid residues
|
| gptkbp:catalyzes |
hydrolysis of N-glycosidic bond
|
| gptkbp:cofactor |
none (generally)
|
| gptkbp:discoveredBy |
gptkb:Tomas_Lindahl
|
| gptkbp:EC_number |
3.2.2.-
|
| gptkbp:example |
gptkb:uracil-DNA_glycosylase
8-oxoguanine DNA glycosylase thymine DNA glycosylase |
| gptkbp:family |
alkyladenine DNA glycosylase family
formamidopyrimidine DNA glycosylase family uracil-DNA glycosylase family |
| gptkbp:foundIn |
prokaryotes
eukaryotes |
| gptkbp:function |
removal of damaged bases from DNA
|
| gptkbp:GO_term |
GO:0003906
|
| https://www.w3.org/2000/01/rdf-schema#label |
DNA glycosylase
|
| gptkbp:involvedIn |
base excision repair
|
| gptkbp:mechanismOfAction |
base flipping
|
| gptkbp:mutationAssociatedWith |
increased mutation rate
|
| gptkbp:product |
apurinic/apyrimidinic (AP) site
|
| gptkbp:requires |
genome stability
|
| gptkbp:significance |
neurodegenerative diseases
cancer susceptibility |
| gptkbp:structure |
varies by family
|
| gptkbp:substrate |
damaged DNA
|
| gptkbp:bfsParent |
gptkb:Base_Excision_Repair
gptkb:CHEBI:15765 |
| gptkbp:bfsLayer |
7
|