DB09223

GPTKB entity

Statements (53)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:approvalYear 2013
gptkbp:ATCCode gptkb:J05AP08
gptkbp:bioavailability ~92%
gptkbp:blackBoxWarning risk of hepatitis B reactivation
gptkbp:CASNumber 1190307-88-0
gptkbp:contraindication coadministration with amiodarone
gptkbp:drugClass antiviral
nucleotide
gptkbp:eliminatedIn renal
gptkbp:eliminationHalfLife 0.4 hours (sofosbuvir), 27 hours (GS-331007)
gptkbp:excretion gptkb:kidney
gptkbp:hasInChIKey YYEJJZCTQZJYQB-AATRIKPKSA-N
gptkbp:hasMetabolite gptkb:GS-331007
gptkbp:hasMolecularFormula C22H29FN3O9P
gptkbp:hasPatentExpiry 2029 (US)
gptkbp:hasPatentHolder gptkb:Gilead_Sciences
gptkbp:hasSMILES CC(C)COC(=O)[C@H](NC(=O)[C@H](N)C(C)C)P(=O)(O)O
gptkbp:hasUNII Q1Q1XK97B3
https://www.w3.org/2000/01/rdf-schema#label DB09223
gptkbp:indication treatment of hepatitis C
gptkbp:isApprovedDrug true
gptkbp:isUsedInCombinationWith gptkb:daclatasvir
ledipasvir
velpatasvir
gptkbp:KEGGID gptkb:D10366
gptkbp:legalStatus prescription only
Rx-only
gptkbp:manufacturer gptkb:Gilead_Sciences
gptkbp:mechanismOfAction NS5B RNA-dependent RNA polymerase inhibitor
gptkbp:metabolism liver
gptkbp:molecularWeight 529.45 g/mol
gptkbp:name gptkb:Sofosbuvir
gptkbp:pregnancyCategory B1 (Australia)
B1 (AU), not assigned (US)
gptkbp:proteinBinding 61-65%
gptkbp:PubChem_CID gptkb:DB09223
gptkb:CHEMBL1259058
45375808
gptkbp:routeOfAdministration oral
gptkbp:sideEffect gptkb:anemia
nausea
fatigue
headache
insomnia
gptkbp:synonym gptkb:Sovaldi
gptkb:GS-7977
gptkb:PSI-7977
gptkbp:target NS5B polymerase
gptkbp:therapeuticArea gptkb:disease
hepatology
gptkbp:bfsParent gptkb:plastic
gptkbp:bfsLayer 4