DB09054

GPTKB entity

Statements (42)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:antidote Idarucizumab
gptkbp:ATCCode B01AE07
gptkbp:bioavailability 6.5%
gptkbp:brand gptkb:Pradaxa
gptkbp:CASNumber 211914-51-1
gptkbp:contraindication patients with active pathological bleeding
patients with mechanical prosthetic heart valves
gptkbp:eliminationHalfLife 12-17 hours
gptkbp:excretion gptkb:kidney
gptkbp:hasInChIKey PTZSUBHDPIDFBE-UHFFFAOYSA-N
gptkbp:hasMolecularFormula C34H41N7O5
gptkbp:hasPatent WO1998000244A1
gptkbp:hasSMILES CC(C)N1C(=O)NC(C(=O)N(C2CC2)C3=CC=CC=C3)C1=O
gptkbp:hasUNII 2ZC835688K
https://www.w3.org/2000/01/rdf-schema#label DB09054
gptkbp:indication prevention of stroke in atrial fibrillation
treatment of venous thromboembolism
gptkbp:legalStatus prescription only
gptkbp:manufacturer gptkb:Boehringer_Ingelheim
gptkbp:mechanismOfAction direct thrombin inhibitor
gptkbp:metabolism liver
gptkbp:molecularWeight 627.74
gptkbp:name gptkb:Dabigatran
gptkbp:pregnancyCategory C (US)
gptkbp:proteinBinding 35%
gptkbp:PubChem_CID gptkb:DB09054
148124
CHEMBL1219
D08143
gptkbp:routeOfAdministration oral
gptkbp:sideEffect bleeding
gastrointestinal upset
gptkbp:status true
gptkbp:synonym gptkb:BIBR_1048
gptkb:Dabigatran_etexilate
gptkbp:target gptkb:thrombin_(F2)
gptkbp:usedFor treatment and prevention of deep vein thrombosis
treatment and prevention of pulmonary embolism
prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation
gptkbp:bfsParent gptkb:idelalisib
gptkbp:bfsLayer 5