DB09031

GPTKB entity

Statements (36)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:ATCCode B01AE07
gptkbp:bioavailability 6.5%
gptkbp:brand gptkb:Pradaxa
gptkbp:CASNumber 211915-06-9
gptkbp:contraindication active pathological bleeding
mechanical prosthetic heart valves
gptkbp:excretion renal
gptkbp:halfLife 12-17 hours
gptkbp:hasBoxedWarning increased risk of thrombotic events after premature discontinuation
risk of spinal/epidural hematoma
gptkbp:hasInChIKey XXRSAYXIQIHRDQ-UHFFFAOYSA-N
gptkbp:hasMolecularFormula C34H41N7O5
gptkbp:hasSMILES CCOC(=O)C[C@@H](N(C)C)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N-
https://www.w3.org/2000/01/rdf-schema#label DB09031
gptkbp:indication treatment and prevention of deep vein thrombosis
treatment and prevention of pulmonary embolism
prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation
gptkbp:legalStatus prescription only
gptkbp:manufacturer gptkb:Boehringer_Ingelheim
gptkbp:mechanismOfAction direct thrombin inhibitor
gptkbp:metabolism liver
gptkbp:molecularWeight 627.74
gptkbp:name gptkb:Dabigatran
gptkbp:pregnancyCategory C (US)
gptkbp:proteinBinding 35%
gptkbp:PubChem_CID gptkb:DB09031
gptkbp:routeOfAdministration oral
gptkbp:sideEffect bleeding
gastrointestinal upset
gptkbp:status true
gptkbp:synonym gptkb:BIBR_1048
gptkb:Dabigatran_etexilate
gptkbp:target gptkb:thrombin
gptkbp:bfsParent gptkb:miltefosine
gptkbp:bfsLayer 6