DB06213

GPTKB entity

Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:approvalYear 2008
gptkbp:ATCCode gptkb:B01AF01
gptkbp:bioavailability 80-100%
gptkbp:brand gptkb:Xarelto
gptkbp:CASNumber 366789-02-8
gptkbp:contraindication active pathological bleeding
severe hypersensitivity to rivaroxaban
gptkbp:drugClass gptkb:anticoagulant
gptkbp:eliminationHalfLife 5-9 hours
gptkbp:excretion urine
feces
gptkbp:hasInChIKey GQSPXLAQXDMGEX-UHFFFAOYSA-N
gptkbp:hasMolecularFormula gptkb:C19H18ClN3O5S
gptkbp:hasSMILES CC1=NN(C2=C1C=CC(=C2)Cl)C(=O)C3=CC=C(C=C3)S(=O)(=O)NC(=O)O
gptkbp:hasUNII Y6O7T4G8P9
https://www.w3.org/2000/01/rdf-schema#label DB06213
gptkbp:indication prevention of venous thromboembolism after hip or knee replacement surgery
treatment of deep vein thrombosis
treatment of pulmonary embolism
prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation
gptkbp:legalStatus prescription only
patented
gptkbp:listedOn gptkb:ChEMBL
gptkb:PubChem
gptkb:DrugBank
gptkb:KEGG
gptkbp:manufacturer gptkb:Bayer
gptkb:Janssen_Pharmaceuticals
gptkbp:mechanismOfAction direct Factor Xa inhibitor
gptkbp:metabolism hepatic (CYP3A4, CYP2J2, CYP-independent)
gptkbp:molecularWeight 435.88
gptkbp:name gptkb:Rivaroxaban
gptkbp:pregnancyCategory C (US)
gptkbp:proteinBinding 92-95%
gptkbp:PubChem_CID gptkb:CHEMBL2010604
gptkb:DB06213
9875401
D08917
68547
gptkbp:routeOfAdministration oral
gptkbp:sideEffect gptkb:anemia
nausea
bleeding
dizziness
gptkbp:status true
gptkbp:synonym gptkb:BAY_59-7939
gptkbp:target gptkb:Factor_Xa
gptkbp:bfsParent gptkb:prucalopride
gptkb:Lexiscan
gptkbp:bfsLayer 7