Xarelto

GPTKB entity

Statements (44)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:antidote andexanet alfa (for reversal)
gptkbp:approvalYear 2008
2011
gptkbp:approvedBy gptkb:Germany
gptkbp:ATCCode gptkb:B01AF01
gptkbp:bioavailability 80-100% (10 mg dose)
gptkbp:CASNumber 366789-02-8
gptkbp:chemicalFormula gptkb:C19H18ClN3O5S
gptkbp:contraindication active pathological bleeding
severe hypersensitivity to rivaroxaban
gptkbp:countryOfOperation gptkb:European_Union
gptkb:United_States
gptkbp:drugClass gptkb:anticoagulant
gptkbp:eliminatedIn renal and fecal
gptkbp:genericName gptkb:rivaroxaban
gptkbp:halfLife 5-9 hours (young), 11-13 hours (elderly)
gptkbp:hasBoxedWarning spinal/epidural hematoma risk
increased risk of thrombotic events after premature discontinuation
https://www.w3.org/2000/01/rdf-schema#label Xarelto
gptkbp:indication prevention of venous thromboembolism after hip or knee replacement surgery
prevention of stroke in atrial fibrillation
treatment of deep vein thrombosis
treatment of pulmonary embolism
gptkbp:legalStatus prescription only
gptkbp:manufacturer gptkb:Bayer
gptkb:Janssen_Pharmaceuticals
gptkbp:marketedAs gptkb:Bayer
gptkb:Janssen_Pharmaceuticals
gptkbp:mechanismOfAction factor Xa inhibitor
gptkbp:patentExpired 2024 (US)
gptkbp:pregnancyCategory C (US)
gptkbp:prescriptionForm gptkb:tablet
oral suspension
gptkbp:riskFactor increased risk of bleeding with other anticoagulants
gptkbp:routeOfAdministration oral
gptkbp:sideEffect gptkb:anemia
nausea
bleeding
dizziness
gptkbp:status FDA approved
gptkbp:synonym gptkb:BAY_59-7939
gptkbp:bfsParent gptkb:Bayer
gptkbp:bfsLayer 5