|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:ATCCode
|
A10BA02
|
|
gptkbp:brand
|
gptkb:Riomet
gptkb:Fortamet
gptkb:Glucophage
gptkb:Glumetza
|
|
gptkbp:CASNumber
|
657-24-9
|
|
gptkbp:contraindication
|
metabolic acidosis
renal impairment
hepatic impairment
|
|
gptkbp:discoveredBy
|
gptkb:Jean_Sterne
|
|
gptkbp:discoveredIn
|
1957
|
|
gptkbp:drugClass
|
biguanide
|
|
gptkbp:eliminationHalfLife
|
4-8.7 hours
|
|
gptkbp:excretion
|
renal
|
|
gptkbp:genericName
|
gptkb:metformin
|
|
gptkbp:hasInChIKey
|
gptkb:XZWYZXLIPXDOLR-UHFFFAOYSA-N
|
|
gptkbp:hasMolecularFormula
|
C4H11N5
|
|
gptkbp:hasSMILES
|
CN(C)C(=N)N=C(N)N
|
|
gptkbp:hasUNII
|
9100L32L2N
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
D02141
|
|
gptkbp:indication
|
gptkb:polycystic_ovary_syndrome
gptkb:type_2_diabetes_mellitus
gptkb:prediabetes
|
|
gptkbp:isApprovedDrug
|
true
|
|
gptkbp:mechanismOfAction
|
decreases hepatic glucose production
increases insulin sensitivity
|
|
gptkbp:metabolism
|
not metabolized
|
|
gptkbp:molecularWeight
|
129.164
|
|
gptkbp:pregnancyCategory
|
B (US)
|
|
gptkbp:PubChem_CID
|
gptkb:D02141
6801
4091
DB00331
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
gastrointestinal upset
lactic acidosis
|
|
gptkbp:usedFor
|
gptkb:type_2_diabetes_mellitus
|
|
gptkbp:bfsParent
|
gptkb:tenofovir_disoproxil_fumarate
gptkb:miltefosine
|
|
gptkbp:bfsLayer
|
6
|