|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activeSiteResidue
|
gptkb:glutamic_acid
cysteine
histidine
|
|
gptkbp:alternativeName
|
gptkb:CDA
cytidine aminohydrolase
|
|
gptkbp:associatedWith
|
cytidine deaminase deficiency
|
|
gptkbp:biologicalProcess
|
pyrimidine nucleoside metabolic process
|
|
gptkbp:catalyzes
|
deamination of cytidine to uridine
deamination of deoxycytidine to deoxyuridine
|
|
gptkbp:cofactor
|
zinc
|
|
gptkbp:discoveredBy
|
1950s
|
|
gptkbp:EC_number
|
3.5.4.5
|
|
gptkbp:Enzyme_Commission_class
|
gptkb:hydrolase
|
|
gptkbp:Enzyme_Commission_sub-subclass
|
in cyclic amidines
|
|
gptkbp:Enzyme_Commission_subclass
|
acting on carbon-nitrogen bonds, other than peptide bonds
|
|
gptkbp:expressedIn
|
gptkb:leukocytes
liver
intestine
|
|
gptkbp:foundIn
|
gptkb:Bacteria
humans
mammals
|
|
gptkbp:gene
|
gptkb:CDA
|
|
gptkbp:HGNC_ID
|
1723
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cytidine deaminase
|
|
gptkbp:inhibitedBy
|
tetrahydrouridine
zebularine
effectiveness of cytidine analog drugs
|
|
gptkbp:involves
|
pyrimidine salvage pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p36.2
|
|
gptkbp:molecular_function_(GO)
|
cytidine deaminase activity
|
|
gptkbp:molecularWeight
|
16 kDa
|
|
gptkbp:mutationAssociatedWith
|
immunodeficiency
|
|
gptkbp:OMIM
|
608208
|
|
gptkbp:orthologInMouse
|
Cda
|
|
gptkbp:orthologInYeast
|
Fcy1
|
|
gptkbp:PDB
|
1MQ0
|
|
gptkbp:product
|
uridine
deoxyuridine
|
|
gptkbp:RefSeq
|
NM_001785
|
|
gptkbp:regulates
|
levels of cytidine analog drugs
|
|
gptkbp:structure
|
homotetramer
|
|
gptkbp:substrate
|
cytidine
deoxycytidine
|
|
gptkbp:target
|
anticancer drugs
|
|
gptkbp:UniProtID
|
P32320
|
|
gptkbp:used_in
|
gptkb:biotechnology
cancer chemotherapy resistance
|
|
gptkbp:bfsParent
|
gptkb:CYD
|
|
gptkbp:bfsLayer
|
8
|