|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:abbreviation
|
gptkb:CFH
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:atypical_hemolytic_uremic_syndrome
age-related macular degeneration
Factor H-like protein 1
Factor H-related proteins (FHR1-5)
dense deposit disease
|
|
gptkbp:binds
|
gptkb:heparin
gptkb:C3b
glycosaminoglycans
sialic acid
|
|
gptkbp:discoveredIn
|
1970s
|
|
gptkbp:encodedBy
|
CFH gene
|
|
gptkbp:Entrez_Gene_ID
|
3075
|
|
gptkbp:expressedIn
|
liver
other tissues
|
|
gptkbp:foundIn
|
gptkb:human
other mammals
|
|
gptkbp:function
|
regulation of complement system
|
|
gptkbp:halfLife
|
~5-7 days
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Complement Factor H
|
|
gptkbp:inhibitedBy
|
C3 convertase
|
|
gptkbp:locatedOnChromosome
|
1q32
|
|
gptkbp:location
|
gptkb:plasma
|
|
gptkbp:medicalUse
|
biomarker for complement activity
|
|
gptkbp:molecularWeight
|
~155 kDa
|
|
gptkbp:mutationAssociatedWith
|
increased risk of complement-mediated diseases
|
|
gptkbp:OMIM
|
134370
|
|
gptkbp:PDB
|
various structures available
|
|
gptkbp:prevention
|
complement activation on host cells
|
|
gptkbp:regulates
|
alternative pathway of complement activation
|
|
gptkbp:reviewedBy
|
gptkb:Nature_Reviews_Immunology
gptkb:Journal_of_Immunology
|
|
gptkbp:structure
|
20 short consensus repeats (SCRs)
|
|
gptkbp:UniProtID
|
P08603
|
|
gptkbp:bfsParent
|
gptkb:CFH
|
|
gptkbp:bfsLayer
|
8
|