Clarithromycin

GPTKB entity

Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:antibiotic
gptkbp:ATCCode gptkb:J01FA09
gptkbp:bioavailability 50%
gptkbp:brand gptkb:Biaxin
gptkb:Klaricid
gptkbp:CASNumber 81103-11-9
gptkbp:category antibacterial drug
gptkbp:contraindication hypersensitivity to macrolides
concomitant use with certain drugs (e.g., statins, ergot derivatives)
gptkbp:discoveredBy gptkb:Taisho_Pharmaceutical
gptkbp:drugClass macrolide
gptkbp:eliminationHalfLife 3–7 hours
gptkbp:excretion urine
feces
gptkbp:hasMolecularFormula C38H69NO13
https://www.w3.org/2000/01/rdf-schema#label Clarithromycin
gptkbp:interactsWith gptkb:rifampicin
gptkb:ergot_alkaloids
gptkb:cyclosporine
gptkb:phenytoin
gptkb:theophylline
gptkb:warfarin
gptkb:carbamazepine
gptkb:digoxin
calcium channel blockers
statins
colchicine
HIV protease inhibitors
gptkbp:introducedIn 1991
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction inhibits bacterial protein synthesis
gptkbp:metabolism liver
gptkbp:pregnancyCategory C (US)
gptkbp:proteinBinding 70–80%
gptkbp:relatedTo gptkb:azithromycin
gptkb:erythromycin
gptkbp:riskOfQTProlongation yes
gptkbp:routeOfAdministration oral
intravenous
gptkbp:sideEffect nausea
diarrhea
abdominal pain
taste disturbance
gptkbp:target 50S ribosomal subunit
gptkbp:usedFor skin infections
bacterial infections
respiratory tract infections
Helicobacter pylori eradication
gptkbp:WHOModelListOfEssentialMedicines yes
gptkbp:bfsParent gptkb:Zentiva
gptkbp:bfsLayer 7