Statements (57)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:neurodegenerative_diseases
metabolic disorders |
| gptkbp:diseases |
gptkb:diabetes
obesity cardiovascular diseases |
| gptkbp:function |
activates AMPK
regulates energy homeostasis |
| https://www.w3.org/2000/01/rdf-schema#label |
Ca MKKβ
|
| gptkbp:initiated_by |
AMPK inhibitor
Ca MKI inhibitor STO-609 |
| gptkbp:interacts_with |
gptkb:AMPK
Ca MKI |
| gptkbp:involved_in |
cell cycle regulation
cellular homeostasis cellular metabolism cellular stress response glucose metabolism immune response lipid metabolism mitochondrial function neurotransmitter release protein synthesis inflammation synaptic plasticity cellular aging cellular differentiation angiogenesis hormonal regulation insulin signaling autophagy cellular communication cellular signaling neurotransmitter synthesis neuronal survival muscle metabolism cellular repair mechanisms cellular adaptation stress granule formation stress response pathways |
| gptkbp:is_expressed_in |
upregulated in response to stress
|
| gptkbp:location |
gptkb:Atom
cytoplasm |
| gptkbp:orthologs |
Ca MKK1
Ca MKK2 |
| gptkbp:pathway |
AMPK signaling pathway
calcium/calmodulin-dependent protein kinase pathway |
| gptkbp:promoter |
CAMKK2
|
| gptkbp:research |
target for cancer therapy
target for metabolic syndrome target for neuroprotection |
| gptkbp:role |
apoptosis regulation
cell proliferation calcium signaling |
| gptkbp:bfsParent |
gptkb:AMP-activated_protein_kinase
|
| gptkbp:bfsLayer |
8
|