|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:discoveredBy
|
Edward M. Brown
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:disorderAssociated
|
gptkb:autosomal_dominant_hypocalcemia
gptkb:familial_hypocalciuric_hypercalcemia
gptkb:neonatal_severe_hyperparathyroidism
|
|
gptkbp:encodedBy
|
CASR gene
|
|
gptkbp:externalLink
|
Ensembl:ENSG00000036549
GeneCards:CASR
NCBI Gene:846
|
|
gptkbp:fullName
|
Calcium-sensing receptor
|
|
gptkbp:function
|
regulation of extracellular calcium homeostasis
|
|
gptkbp:gene
|
gptkb:CASR
|
|
gptkbp:HGNC_ID
|
1514
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CaSR
|
|
gptkbp:inhibitedBy
|
parathyroid hormone secretion
|
|
gptkbp:ligand
|
gptkb:calcium_ion
|
|
gptkbp:locatedOnChromosome
|
3q13.3-q21
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
~120 kDa
|
|
gptkbp:OMIM
|
601199
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
gptkb:Gi/o_protein_pathway
Gq/11 protein pathway
|
|
gptkbp:PDB
|
5K5S
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:structure
|
gptkb:G_protein-coupled_receptor
|
|
gptkbp:tissue_specificity
|
gptkb:bone
gptkb:kidney
brain
gastrointestinal tract
parathyroid gland
|
|
gptkbp:UniProtID
|
P41180
|
|
gptkbp:bfsParent
|
gptkb:CASR
|
|
gptkbp:bfsLayer
|
7
|