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gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:cholera_toxin
|
|
gptkbp:biosafetyLevel
|
gptkb:BSL-2
|
|
gptkbp:category
|
gptkb:enterotoxin
gptkb:bacterial_exotoxin
|
|
gptkbp:component
|
Vibrio cholerae pathogenicity
|
|
gptkbp:discoveredBy
|
gptkb:Sambhu_Nath_De
|
|
gptkbp:discoveredIn
|
1959
|
|
gptkbp:effect
|
causes watery diarrhea
increases cAMP in host cells
causes secretion of chloride ions
|
|
gptkbp:effectOnHost
|
dehydration
electrolyte imbalance
|
|
gptkbp:gene
|
gptkb:ctxB
ctxA
|
|
gptkbp:inhibitedBy
|
cholera toxin inhibitors
|
|
gptkbp:mechanismOfAction
|
ADP-ribosylation of Gs alpha protein
|
|
gptkbp:molecularWeight
|
~84 kDa
|
|
gptkbp:PDB
|
gptkb:1XTC
|
|
gptkbp:producedBy
|
gptkb:Vibrio_cholerae
|
|
gptkbp:recipient
|
gptkb:GM1_ganglioside
|
|
gptkbp:structure
|
gptkb:AB5_toxin
|
|
gptkbp:subunitA
|
A subunit
|
|
gptkbp:subunitB
|
B subunit
|
|
gptkbp:target
|
intestinal epithelial cells
|
|
gptkbp:transmittedBy
|
gptkb:CTXφ_bacteriophage
|
|
gptkbp:UniProtID
|
gptkb:P01555_(A_subunit)
gptkb:P01556_(B_subunit)
|
|
gptkbp:usedAs
|
mucosal adjuvant
|
|
gptkbp:usedIn
|
immunology research
|
|
gptkbp:bfsParent
|
gptkb:CTX
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CTX (Cholera toxin)
|