Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
genomic element
|
| gptkbp:associatedWith |
chromatin looping
enhancer blocking |
| gptkbp:bindingAffinity |
varies by sequence context
|
| gptkbp:database |
gptkb:ENCODE
JASPAR |
| gptkbp:discoveredBy |
Phillips and Corces
|
| gptkbp:firstDescribed |
1990s
|
| gptkbp:foundIn |
eukaryotic genomes
|
| gptkbp:function |
insulator
chromatin organization transcriptional regulation |
| https://www.w3.org/2000/01/rdf-schema#label |
CTCF binding sites
|
| gptkbp:involves |
gptkb:cancer
gptkb:X-chromosome_inactivation developmental disorders genomic imprinting |
| gptkbp:motif |
CCCTC-binding factor motif
|
| gptkbp:numberInHumanGenome |
~50,000
|
| gptkbp:recognizedBy |
gptkb:CTCF_protein
|
| gptkbp:role |
gene expression regulation
topologically associating domain boundaries |
| gptkbp:sequenceSpecificity |
gptkb:gene
|
| gptkbp:studiedIn |
human genome
mouse genome Drosophila genome |
| gptkbp:bfsParent |
gptkb:ICR1
|
| gptkbp:bfsLayer |
7
|