paroxysmal nocturnal hemoglobinuria
GPTKB entity
Statements (34)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:disease
gptkb:hematologic_disorder |
| gptkbp:affects |
red blood cells
platelets white blood cells |
| gptkbp:alsoKnownAs |
gptkb:PNH
|
| gptkbp:causedBy |
acquired mutation in PIGA gene
|
| gptkbp:characterizedBy |
thrombosis
bone marrow failure hemolysis |
| gptkbp:complication |
renal failure
stroke pulmonary embolism |
| gptkbp:diagnosedBy |
gptkb:Ham's_test
flow cytometry |
| gptkbp:firstDescribed |
gptkb:Paul_Strübing
1882 |
| gptkbp:ICD-10_code |
D59.5
|
| gptkbp:inheritance |
acquired, not inherited
|
| gptkbp:MeSH_ID |
D010474
|
| gptkbp:OMIM |
300818
|
| gptkbp:prevalence |
rare
|
| gptkbp:riskFactor |
aplastic anemia
myelodysplastic syndrome |
| gptkbp:symptom |
abdominal pain
fatigue dyspnea hemoglobinuria |
| gptkbp:treatment |
gptkb:eculizumab
gptkb:ravulizumab bone marrow transplant |
| gptkbp:bfsParent |
gptkb:Apellis_Pharmaceuticals
|
| gptkbp:bfsLayer |
7
|
| https://www.w3.org/2000/01/rdf-schema#label |
paroxysmal nocturnal hemoglobinuria
|