paroxysmal nocturnal hemoglobinuria

GPTKB entity

Statements (34)
Predicate Object
gptkbp:instanceOf gptkb:disease
hematologic disorder
gptkbp:affects red blood cells
platelets
white blood cells
gptkbp:alsoKnownAs gptkb:PNH
gptkbp:causedBy acquired mutation in PIGA gene
gptkbp:characterizedBy thrombosis
bone marrow failure
hemolysis
gptkbp:complication renal failure
stroke
pulmonary embolism
gptkbp:diagnosedBy gptkb:Ham's_test
flow cytometry
gptkbp:firstDescribed gptkb:Paul_StrĂ¼bing
1882
https://www.w3.org/2000/01/rdf-schema#label paroxysmal nocturnal hemoglobinuria
gptkbp:ICD-10_code D59.5
gptkbp:inheritance acquired, not inherited
gptkbp:MeSH_ID D010474
gptkbp:OMIM 300818
gptkbp:prevalence rare
gptkbp:riskFactor aplastic anemia
myelodysplastic syndrome
gptkbp:symptom abdominal pain
fatigue
dyspnea
hemoglobinuria
gptkbp:treatment gptkb:eculizumab
gptkb:ravulizumab
bone marrow transplant
gptkbp:bfsParent gptkb:Hemoglobinuria
gptkbp:bfsLayer 6