paroxysmal nocturnal hemoglobinuria
GPTKB entity
Statements (34)
Predicate | Object |
---|---|
gptkbp:instanceOf |
gptkb:disease
hematologic disorder |
gptkbp:affects |
red blood cells
platelets white blood cells |
gptkbp:alsoKnownAs |
gptkb:PNH
|
gptkbp:causedBy |
acquired mutation in PIGA gene
|
gptkbp:characterizedBy |
thrombosis
bone marrow failure hemolysis |
gptkbp:complication |
renal failure
stroke pulmonary embolism |
gptkbp:diagnosedBy |
gptkb:Ham's_test
flow cytometry |
gptkbp:firstDescribed |
gptkb:Paul_StrĂ¼bing
1882 |
https://www.w3.org/2000/01/rdf-schema#label |
paroxysmal nocturnal hemoglobinuria
|
gptkbp:ICD-10_code |
D59.5
|
gptkbp:inheritance |
acquired, not inherited
|
gptkbp:MeSH_ID |
D010474
|
gptkbp:OMIM |
300818
|
gptkbp:prevalence |
rare
|
gptkbp:riskFactor |
aplastic anemia
myelodysplastic syndrome |
gptkbp:symptom |
abdominal pain
fatigue dyspnea hemoglobinuria |
gptkbp:treatment |
gptkb:eculizumab
gptkb:ravulizumab bone marrow transplant |
gptkbp:bfsParent |
gptkb:Hemoglobinuria
|
gptkbp:bfsLayer |
6
|