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gptkbp:instanceOf
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gptkb:protein
|
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gptkbp:alternativeName
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multifunctional protein CAD
carbamoyl-phosphate synthetase 2/aspartate transcarbamylase/dihydroorotase
CPSase II/ATCase/DHOase protein
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gptkbp:associatedWith
|
congenital disorder of glycosylation, type Iz
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gptkbp:domain
|
gptkb:aspartate_transcarbamylase
gptkb:carbamoyl-phosphate_synthetase
gptkb:dihydroorotase
glutamine amidotransferase
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gptkbp:encodedBy
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gptkb:CAD_gene
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gptkbp:foundIn
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gptkb:Homo_sapiens
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gptkbp:function
|
pyrimidine biosynthesis
|
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gptkbp:hasBiologicalActivity
|
gptkb:aspartate_transcarbamylase
gptkb:carbamoyl-phosphate_synthetase
gptkb:dihydroorotase
|
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https://www.w3.org/2000/01/rdf-schema#label
|
CAD protein
|
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gptkbp:involvedIn
|
de novo pyrimidine nucleotide biosynthetic process
|
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gptkbp:isMultifunctional
|
true
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gptkbp:locatedOnChromosome
|
2p21
|
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gptkbp:molecularWeight
|
~243 kDa
|
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gptkbp:OMIM
|
114010
|
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gptkbp:organism
|
gptkb:human
|
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gptkbp:orthologIn
|
mouse CAD protein
rat CAD protein
|
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gptkbp:phosphorylates
|
Ser1406
Ser1859
Thr456
|
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gptkbp:subcellularLocation
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gptkb:cytoplasm
|
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gptkbp:target
|
regulation by MAPK pathway
regulation by mTOR pathway
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gptkbp:UniProtID
|
P27708
|
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gptkbp:bfsParent
|
gptkb:CAD_gene
gptkb:Carbamoyl-phosphate_synthetase_2,_aspartate_transcarbamylase,_and_dihydroorotase_(CAD)_protein
|
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gptkbp:bfsLayer
|
8
|