|
gptkbp:instanceOf
|
gptkb:chemical_compound
|
|
gptkbp:adverse_effect
|
nausea
vomiting
nephrotoxicity
neurotoxicity
ototoxicity
myelosuppression
|
|
gptkbp:approvalYear
|
1978
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
L01XA01
|
|
gptkbp:CASNumber
|
15663-27-1
|
|
gptkbp:color
|
yellow
|
|
gptkbp:discoveredBy
|
gptkb:Barnett_Rosenberg
|
|
gptkbp:discoveredIn
|
1965
|
|
gptkbp:drugClass
|
platinum-based antineoplastic agent
|
|
gptkbp:has_ChemIDplus_ID
|
15663-27-1
|
|
gptkbp:has_EINECS_number
|
239-733-8
|
|
gptkbp:has_FDA_label
|
https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/018057s067lbl.pdf
|
|
gptkbp:has_KEGG_Drug_ID
|
D00275
|
|
gptkbp:has_physical_form
|
crystalline solid
|
|
gptkbp:has_RxNorm_ID
|
1976
|
|
gptkbp:has_UN_number
|
UN 3288
|
|
gptkbp:hasInChIKey
|
KURNBZPLTSTZSP-UHFFFAOYSA-L
|
|
gptkbp:hasMolecularFormula
|
Cl2H6N2Pt
|
|
gptkbp:hasSMILES
|
N.N.Cl[Pt](Cl)N
|
|
gptkbp:hasUNII
|
Q20Q21Q62J
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
C11193
|
|
gptkbp:is_cytotoxic
|
true
|
|
gptkbp:is_on_WHO_Model_List_of_Essential_Medicines
|
true
|
|
gptkbp:IUPACName
|
gptkb:cis-diamminedichloroplatinum(II)
|
|
gptkbp:mechanismOfAction
|
DNA crosslinking agent
|
|
gptkbp:meltingPoint
|
270°C (decomposes)
|
|
gptkbp:MeSH_ID
|
D002945
|
|
gptkbp:molecularWeight
|
300.05 g/mol
|
|
gptkbp:PubChem_CID
|
441203
CHEBI:27899
DB00515
38933
|
|
gptkbp:routeOfAdministration
|
intravenous
|
|
gptkbp:solubility
|
slightly soluble
|
|
gptkbp:storage
|
store at room temperature
|
|
gptkbp:synonym
|
gptkb:cisplatin
gptkb:cis-diamminedichloroplatinum(II)
cis-DDP
|
|
gptkbp:usedFor
|
gptkb:cancer
testicular cancer
bladder cancer
head and neck cancer
|
|
gptkbp:bfsParent
|
gptkb:malathion
|
|
gptkbp:bfsLayer
|
8
|